770-30-9

Usage

Uses

Used in Pharmaceutical Industry:
4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE is used as a pharmaceutical intermediate for the synthesis of various therapeutic agents. Its unique chemical structure allows it to be a key component in the development of drugs targeting specific biological pathways and diseases.
As a pharmaceutical intermediate, 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE plays a crucial role in the production of medications that address a wide range of health conditions. Its versatility in chemical reactions enables the creation of diverse drug candidates with potential applications in various therapeutic areas.

InChI:InChI=1/C6H7N3OS/c1-11-6-8-2-4(3-10)5(7)9-6/h2-3H,1H3,(H2,7,8,9)

Upstream product

• 14527-26-5 2-methylisothiourea sulphate 
• 123-06-8 Ethoxymethylenemalononitrile 
• 4338-95-8 S-methylthiouronium iodide 
• 147895-43-0 S-methylisothiourea hemisulphate 
• 867-44-7 S-Methylisothiourea sulfate 

Downstream Products

• 98198-13-1 4-amino-2-methanesulfonyl-pyrimidine-5-carbonitrile 
• 724702-31-2 4-amino-2-(4-phenylpiperazin-1-yl)pyrimidine-5-carbonitrile 
• 918662-96-1 N-(2-butylamino-5-cyano-pyrimidin-4-yl)-benzamide 
• 1019017-12-9 4-amino-2-(4-benzyl-piperazin-1-yl)-pyrimidine-5-carbonitrile 
• 918662-89-2 N-(5-cyano-2-morpholin-4-yl-pyrimidin-4-yl)-benzamide 
• 918662-90-5 N-(5-cyano-2-piperidin-1-yl-pyrimidin-4-yl)-benzamide 
• 1026736-73-1 4-amino-2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-pyrimidine-5-carbonitrile 
• 918662-94-9 N-[5-cyano-2-(4-methyl-piperazin-1-yl)-pyrimidin-4-yl]-benzamide 
• 918662-98-3 N-(5-cyano-2-cyclohexylamino-pyrimidin-4-yl)-benzamide 
• 918662-97-2 N-(5-cyano-2-hexylamino-pyrimidin-4-yl)-benzamide 
• 918662-93-8 N-[5-cyano-2-(3,4-dihydro-2H-quinolin-1-yl)-pyrimidin-4-yl]-benzamide 
• 918662-95-0 N-[5-cyano-2-(4-phenyl-piperazin-1-yl)-pyrimidin-4-yl]-benzamide 
• 918662-91-6 N-[2-(4-benzyl-piperazin-1-yl)-5-cyano-pyrimidin-4-yl]-benzamide 
• 918662-92-7 N-{5-cyano-2-[4-(2-methoxy-phenyl)-piperazin-1-yl]-pyrimidin-4-yl}-benzamide 

Relevant academic research and scientific papers

Synthesis and anticancer activity of novel 2-alkylthio-4-amino-5-(thiazol-2-YL)pyrimidines

A series of new fist-time synthesized of thiazolyl-substituted 4-aminopyrimidine was obtained on the basis of a two-stage process including thioamidation of 4-amino-5-cyanopyrimide followed by one-pot acylation and Hantzsch synthesis in good yield (52–77%

BIVALENT NUCLEIC ACID LIGANDS AND USES THEREFOR

Genetic recognition reagents comprising bivalent nucleobases are provided that bind two strands of nucleic acid, such as an expanded repeat sequence associated with an expanded repeat disease. In one example the expanded repeat disease is a polyQ disease, such as Huntington's disease. Methods of use of the reagents are provided, including a method of binding nucleic acid, such as an expanded repeat sequence associated with an expanded repeat disease, a method of identifying the presence of a nucleic acid comprising an expanded repeat, and a method of treating an expanded repeat disease are provided.

DIVALENT NUCLEOBASE COMPOUNDS AND USES THEREFOR

Described herein are novel divalent nucleobases that each bind two nucleic acid strands, matched or mismatched when incorporated into a nucleic acid or nucleic acid analog backbone (a genetic recognition reagent, or genetic recognition reagent). In one embodiment, the genetic recognition reagent is a peptide nucleic acid (PNA) or gamma PNA (?PNA) oligomer. Uses of the divalent nucleobases and monomers and genetic recognition reagents containing the divalent nucleobases also are provided.

Facile synthesis of pyrazolo[3,4-d]pyrimidines and pyrimido[4,5-d] pyrimidin-4-one derivatives

Pyrazolopyrimidine and pyrimidopyrimidine derivatives have shown a wide range of biological activities such as acting as A1 adenosine receptors, kinase insert domain receptor (KDR), Rous sarcoma oncogene (Src), epidermal growth factor receptor (EGFR), antiproliferative, dihydrofolate reductase (DHFR), antimicrobial, antifungal, and lipid peroxidation. Because of this wide range of activities, we have synthesized pyrazolo[3,4-d]pyrimidines and pyrimido[4,5-d]pyrimidin-4-one derivatives. Copyright Taylor & Francis Group, LLC.