L-Valine, N-[[(2R,4R,5R)-1-[(1,1-dimethylethoxy)carbonyl]-4-[3-[[(1,1-dimethyleth yl)dimethylsilyl]oxy]phenyl]-4,5-dimethyl-2-piperidinyl]carbonyl]-, methyl ester

Base Information

Chemical Name:L-Valine, N-[[(2R,4R,5R)-1-[(1,1-dimethylethoxy)carbonyl]-4-[3-[[(1,1-dimethyleth yl)dimethylsilyl]oxy]phenyl]-4,5-dimethyl-2-piperidinyl]carbonyl]-, methyl ester
CAS No.:918829-79-5
Molecular Formula:C31H52N2O6Si
Molecular Weight:576.849
Hs Code.:

L-Valine,
N-[[(2R,4R,5R)-1-[(1,1-dimethylethoxy)carbonyl]-4-[3-[[(1,1-dimethyleth
yl)dimethylsilyl]oxy]phenyl]-4,5-dimethyl-2-piperidinyl]carbonyl]-, methyl
ester

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of L-Valine, N-[[(2R,4R,5R)-1-[(1,1-dimethylethoxy)carbonyl]-4-[3-[[(1,1-dimethyleth yl)dimethylsilyl]oxy]phenyl]-4,5-dimethyl-2-piperidinyl]carbonyl]-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of L-Valine, N-[[(2R,4R,5R)-1-[(1,1-dimethylethoxy)carbonyl]-4-[3-[[(1,1-dimethyleth yl)dimethylsilyl]oxy]phenyl]-4,5-dimethyl-2-piperidinyl]carbonyl]-, methyl ester

There total 5 articles about L-Valine, N-[[(2R,4R,5R)-1-[(1,1-dimethylethoxy)carbonyl]-4-[3-[[(1,1-dimethyleth yl)dimethylsilyl]oxy]phenyl]-4,5-dimethyl-2-piperidinyl]carbonyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 918829-63-7
(2R,4R,5R)-1-(tert-butoxycarbonyl)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-4,5-dimethylpiperidine-2-carboxylic acid

: 6306-52-1
L-valine methylester hydrochloride

: 918829-79-5
tert-butyl (2R,4R,5R)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-2-((S)-1-methoxy-3-methyl-1-oxobutan-2-ylcarbamoyl)-4,5-dimethylpiperidine-1-carboxylate

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃;

Reference yield: 75.0%

: 918829-63-7
(2R,4R,5R)-1-(tert-butoxycarbonyl)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-4,5-dimethylpiperidine-2-carboxylic acid

: 4070-48-8
L-Valine methyl ester

: 918829-79-5
tert-butyl (2R,4R,5R)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-2-((S)-1-methoxy-3-methyl-1-oxobutan-2-ylcarbamoyl)-4,5-dimethylpiperidine-1-carboxylate

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃;
DOI:10.1021/jm0604878

Reference yield:

: 918829-62-6
tert-butyl (3R,4R)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-3,4-dimethylpiperidine-1-carboxylate

: 918829-79-5
tert-butyl (2R,4R,5R)-4-(3-(tert-butyldimethylsilyloxy)phenyl)-2-((S)-1-methoxy-3-methyl-1-oxobutan-2-ylcarbamoyl)-4,5-dimethylpiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N,N',N'-tetramethylenediamine; sec-butyllithium / diethyl ether; cyclohexane / 4.5 h / -78 °C

1.2: 73 percent / diethyl ether; cyclohexane / -78 - 20 °C

2.1: 75 percent / N,N-diisopropylethylamine; TBTU / acetonitrile / 20 °C

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In diethyl ether; cyclohexane; acetonitrile;
DOI:10.1021/jm0604878