1-[(4S)-4-Benzyl-2,2,5,5-tetramethyl-1,3-oxazolidin-3-yl]ethan-1-one

Base Information

Chemical Name:1-[(4S)-4-Benzyl-2,2,5,5-tetramethyl-1,3-oxazolidin-3-yl]ethan-1-one
CAS No.:918830-50-9
Molecular Formula:C16H23NO2
Molecular Weight:261.364
Hs Code.:
DSSTox Substance ID:DTXSID00580236
Nikkaji Number:J2.406.560J
Wikidata:Q82471014

Synonyms:918830-50-9;(S)-1-(4-Benzyl-2,2,5,5-tetramethyloxazolidin-3-yl)ethanone;DTXSID00580236;1-[(4S)-4-Benzyl-2,2,5,5-tetramethyl-1,3-oxazolidin-3-yl]ethan-1-one

Suppliers and Price of 1-[(4S)-4-Benzyl-2,2,5,5-tetramethyl-1,3-oxazolidin-3-yl]ethan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[(4S)-4-Benzyl-2,2,5,5-tetramethyl-1,3-oxazolidin-3-yl]ethan-1-one

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:261.172878976
Heavy Atom Count:19
Complexity:343

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)N1C(C(OC1(C)C)(C)C)CC2=CC=CC=C2
Isomeric SMILES:CC(=O)N1[C@H](C(OC1(C)C)(C)C)CC2=CC=CC=C2

Technology Process of 1-[(4S)-4-Benzyl-2,2,5,5-tetramethyl-1,3-oxazolidin-3-yl]ethan-1-one

There total 2 articles about 1-[(4S)-4-Benzyl-2,2,5,5-tetramethyl-1,3-oxazolidin-3-yl]ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 144899-42-3
(4S)-2,2,5,5-tetramethyl-4-phenylmethyloxazolidine

: 75-36-5
acetyl chloride

: 918830-50-9
1-((S)-4-benzyl-2,2,5,5-tetramethyloxazolidin-3-yl)ethanone

Guidance literature:: With triethylamine; In dichloromethane; at 5 ℃; for 0.5h;
DOI:10.1021/ja065605v

Reference yield:

: 170918-41-9
(S)-2-amino-3-phenyl-1,1-dimethylpropanol

: 918830-50-9
1-((S)-4-benzyl-2,2,5,5-tetramethyloxazolidin-3-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: MgSO₄ / 0.5 h

2: 4.4 g / Et₃N / CH₂Cl₂ / 0.5 h / 5 °C

With magnesium sulfate; triethylamine; In dichloromethane;
DOI:10.1021/ja065605v

Reference yield:

: 918830-50-9
1-((S)-4-benzyl-2,2,5,5-tetramethyloxazolidin-3-yl)ethanone

: 5908-41-8
benzoyltrimethylsilane

: 100-39-0
benzyl bromide

: 1-((S)-4-Benzyl-2,2,5,5-tetramethyl-oxazolidin-3-yl)-3,4-diphenyl-3-trimethylsilanyloxy-butan-1-one

Guidance literature:: 1-((S)-4-benzyl-2,2,5,5-tetramethyloxazolidin-3-yl)ethanone; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 - 0 ℃;

benzoyltrimethylsilane; In tetrahydrofuran; hexane; at 0 ℃; for 0.25h;

benzyl bromide; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 12h;
DOI:10.1021/ja065605v