N-Butyl-2-cyclopropylbenzamide

Base Information

Chemical Name:N-Butyl-2-cyclopropylbenzamide
CAS No.:918867-69-3
Molecular Formula:C14H19NO
Molecular Weight:217.311
Hs Code.:
DSSTox Substance ID:DTXSID30579956
Nikkaji Number:J2.411.195D
Wikidata:Q82470644

Synonyms:N-Butyl-2-cyclopropylbenzamide;918867-69-3;DTXSID30579956

Suppliers and Price of N-Butyl-2-cyclopropylbenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of N-Butyl-2-cyclopropylbenzamide

Chemical Property:

XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:5
Exact Mass:217.146664230
Heavy Atom Count:16
Complexity:235

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCCCNC(=O)C1=CC=CC=C1C2CC2

Technology Process of N-Butyl-2-cyclopropylbenzamide

There total 4 articles about N-Butyl-2-cyclopropylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 2-cyclopropylbenzoyl chloride

: 109-73-9,85404-21-3
N-butylamine

: 918867-69-3
N-butyl-2-cyclopropylbenzamide

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1021/ol062476e

Reference yield:

: 57807-28-0
1-bromo-2-cyclopropylbenzene

: 918867-69-3
N-butyl-2-cyclopropylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / cooling

1.2: 60 percent / hexane; tetrahydrofuran / 0.5 h / 20 °C

2.1: thionyl chloride / 1 h / 65 °C

3.1: 95 percent / triethylamine / CH₂Cl₂

With n-butyllithium; thionyl chloride; triethylamine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ol062476e

Reference yield:

: 2039-88-5
2-bromostyrene

: 918867-69-3
N-butyl-2-cyclopropylbenzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: diethyl zinc; trifluoroacetic acid / CH₂Cl₂; hexane / 20 h / cooling

1.2: 93 percent / CH₂Cl₂; hexane / 0.5 h / cooling

2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / cooling

2.2: 60 percent / hexane; tetrahydrofuran / 0.5 h / 20 °C

3.1: thionyl chloride / 1 h / 65 °C

4.1: 95 percent / triethylamine / CH₂Cl₂

With n-butyllithium; thionyl chloride; diethylzinc; triethylamine; trifluoroacetic acid; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ol062476e