57807-28-0

Usage

Uses

Used in Pharmaceutical Industry:
1-Bromo-2-cyclopropylbenzene is used as a synthetic building block for the creation of various pharmaceuticals. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 1-Bromo-2-cyclopropylbenzene is utilized as a precursor in the synthesis of agrochemicals, contributing to the development of effective pesticides and other agricultural products.
Used in Materials Science:
1-Bromo-2-cyclopropylbenzene is employed as a starting material in the research and development of new materials with potential applications in various industries, including electronics, plastics, and coatings.
Used as a Reagent in Chemical Reactions:
1-Bromo-2-cyclopropylbenzene is used as a reagent, particularly for the formation of carbon-carbon bonds, facilitating the synthesis of complex organic molecules in chemical reactions.
Used in Research and Development:
1-Bromo-2-cyclopropylbenzene is also used in research settings as a starting material for the exploration and creation of new chemicals and materials with possible industrial applications.
Safety Note:
It is crucial to handle 1-Bromo-2-cyclopropylbenzene with care due to its toxic nature, which can cause skin and eye irritation upon contact. Proper safety measures should be taken to minimize health risks during its use.

InChI:InChI=1/C9H9Br/c10-9-4-2-1-3-8(9)7-5-6-7/h1-4,7H,5-6H2

Upstream product

• 75-11-6 diiodomethane 
• 2039-88-5 2-bromostyrene 
• 583-55-1 1-Bromo-2-iodobenzene 
• 411235-57-9 cyclopropylboronic acid 
• 873-49-4 cyclopropylbenzene 

Downstream Products

• 3158-74-5 2-cyclopropylbenzoic acid 
• 1415578-28-7 C₂₇H₂₇Bi 
• 1415578-29-8 C₂₇H₂₇BiCl₂ 
• 50564-92-6 2-benzyl-3,3-dimethylisoindolin-1-one 
• 39774-23-7 1-oxo-3-methyl-2-phenylmethyl-1,2-dihydroisoquinoline 
• 53890-83-8 2-phenyl-3,3-dimethylisoindoline-1-one 

Relevant academic research and scientific papers

BCL-2 INHIBITOR

Disclosed herein is a compound of Formula (I) for inhibiting both Bcl-2 wild type and mutated Bcl-2, in particular, Bcl-2 G101V and D103Y, and a method of using the compound disclosed herein for treating dysregulated apoptotic diseases.

Silylium-Ion-Promoted Ring-Opening Hydrosilylation and Disilylation of Unactivated Cyclopropanes

A silylium-ion-promoted ring-opening hydrosilylation of unactivated cyclopropanes is reported. The reaction is facilitated by the γ-silicon effect, and the regioselectivity is influenced by various stabilizing effects on the carbenium-ion intermediates, including the β-silicon effect. The experimental observations are in accord with the computed reaction mechanism. The work also showcases the ability of silylium ions to isomerize cyclopropyl to allyl groups, and the resulting α-olefins engage in a silylium-ion-mediated disilylation with hexamethyldisilane.

Bcl-2 INHIBITORS

Disclosed herein is a compound of Formula (I) for inhibiting Bcl-2 and treating disease associated with undesirable bcl-2 activity (Bcl-2 related diseases), a method of using the compounds disclosed herein for treating dysregulated apoptotic diseases including cancers and treating autoimmune disease, and a pharmaceutical composition comprising the same.

PURINONES AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS

The application relates to inhibitors of USP1 useful in the treatment of cancers, and other USP1 associated diseases and disorders, having the Formula: (I), where R1, R2, R3, R3', R4, R5, X1, X2, X3, X4, and n are described herein.

HERBICIDE COMPOSITION

There is provided a herbicidal composition containing a cyclohexanone compound represented by Formula (I) and at least one compound selected from Group A. Group A: consisting of benoxacor, cloquintocet-mexyl, cyometrinil, dichlormid, fenchlorazole-ethyl,

CYCLOHEXANONE COMPOUNDS AND HERBICIDES COMPRISING THE SAME

The present invention provides a compound having an excellent efficacy for controlling weeds. A cyclohexanone compound of the formula (I): wherein m is an integer of 1, 2 or 3; n is an integer of any one of 1 to 5; X represents CH2, O, S, S(O)

An efficient synthesis of 3-substituted N-glycoside indoles useful as sodium-dependent glucose transporter inhibitors

A practical synthesis of two N-glycoside indoles 1 and 2, identified as highly potent sodium-dependent glucose transporter (SGLT) inhibitors is described. Highlights of the synthetic process include a selective and quantitative Vilsmeier acylation and a h

PROCESS FOR THE PREPARATION OF COMPOUNDS USEFUL AS INHIBITORS OF SGLT-2

The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney.

Palladium-catalyzed oxidative activation of arylcyclopropanes

(Diagram presented) Palladium chloride-catalyzed intramolecular activation of electroneutral cyclopropane derivatives results in cleavage of the cyclopropane ring followed by formation of heterocyclic derivatives. Phenols, carboxylic acids, and amide groups were considered as substituents ortho to the cyclopropane ring in this catalytic activation chemistry. The regioselectivity observed in the case of amide-containing substrates was different from that of carboxylic acid-containing substrates, ruling out simple cyclopropane isomerization followed by a Wacker oxidation as the mechanistic pathway.