6G57A9FA8E

Base Information

• Chemical Name: 6G57A9FA8E
• CAS No.: 918867-88-6
• Molecular Formula: C30H40N2O7S
• Molecular Weight: 572.723
• UNII: 6G57A9FA8E
• Mol file: 918867-88-6.mol

Synonyms:918867-88-6;6G57A9FA8E;UNII-6G57A9FA8E;(R)-5-(2-(Bis(2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide;5-((2R)-2-(Bis(2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide;5-((R)-2-(Bis-(2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide;5-[(2R)-2-[bis[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide;Benzenesulfonamide, 5-((2R)-2-(bis(2-(2-ethoxyphenoxy)ethyl)amino)propyl)-2-methoxy-;N-[2-(2-Ethoxyphenoxy)ethyl]-(R)-Tamsulosin;SCHEMBL4618580;Tamsulosin hydrochloride impurity A [EP];TAMSULOSIN HYDROCHLORIDE IMPURITY A [EP IMPURITY]

Chemical Property of 6G57A9FA8E

Chemical Property:

• PSA: 117.93000
• LogP: 6.31210
• XLogP3: 5.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 17
• Exact Mass: 572.25562279
• Heavy Atom Count: 40
• Complexity: 763

Purity/Quality:

>95% ^*data from raw suppliers

N-[2-(2-Ethoxyphenoxy)ethyl]-(R)-Tamsulosin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=CC=C1OCCN(CCOC2=CC=CC=C2OCC)C(C)CC3=CC(=C(C=C3)OC)S(=O)(=O)N
• Isomeric SMILES: CCOC1=CC=CC=C1OCCN(CCOC2=CC=CC=C2OCC)[C@H](C)CC3=CC(=C(C=C3)OC)S(=O)(=O)N
• Uses: N-[2-(2-Ethoxyphenoxy)ethyl]-(R)-Tamsulosin (Tamsulosin EP Impurity A) is derived from 5-[(2R)-2-Aminopropyl]-2-methoxybenzenesulfonamide (A628695), which is a precursor in the synthesis of Tamsulosin (T006350) and other alpha-andregenic antagonists. (R)-Tamsulosin is a specific α1-adrenoceptor antagonist. It is used in the treatment of benign prostatic hypertrophy.

Technology Process of 6G57A9FA8E

There total 2 articles about 6G57A9FA8E which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2-(o-ethoxyphenoxy)-ethyl bromide (3259-03-8) + 5-((R)-2-amino-1-propyl)-2-methoxybenzenesulphonamide (112101-81-2) → 5-((R)-2-{bis-[2-(2-ethoxyphenoxy)ethyl]amino}-propyl)-2-methoxybenzenesulfonamide (918867-88-6)

Guidance literature:

With sodium oxalate; In N,N-dimethyl-formamide; at 80 ℃;

Reference yield:

2-(o-ethoxyphenoxy)-ethyl bromide (3259-03-8) + 5-((R)-2-amino-1-propyl)-2-methoxybenzenesulphonamide (112101-81-2) → 1,2-bis(2-ethoxyphenoxy)ethane (858583-36-5) + N-(2-(2-ethoxyphenoxy)ethyl)-5-(2-(2-(2-ethoxyphenoxy)ethylamino)-1-propyl)-2-methoxybenzenesulphonamide + 5-((R)-2-{bis-[2-(2-ethoxyphenoxy)ethyl]amino}-propyl)-2-methoxybenzenesulfonamide (918867-88-6) + tamsulosin hydrochloride (106133-20-4,80223-99-0,128332-25-2)

Guidance literature:

2-(o-ethoxyphenoxy)-ethyl bromide; 5-((R)-2-amino-1-propyl)-2-methoxybenzenesulphonamide; In methanol; for 43 - 45h; Heating / reflux;

With hydrogenchloride; In ethanol; at 0 ℃; for 4h; Product distribution / selectivity;

upstream raw materials:

2-(o-ethoxyphenoxy)-ethyl bromide

5-((R)-2-amino-1-propyl)-2-methoxybenzenesulphonamide