1-(2-Bromoethoxy)-2-ethoxybenzene

Base Information

• Chemical Name: 1-(2-Bromoethoxy)-2-ethoxybenzene
• CAS No.: 3259-03-8
• Molecular Formula: C₁₀H₁₃BrO₂
• Molecular Weight: 245.116
• Hs Code.: 2909309090
• UNII: GMJ3274102
• DSSTox Substance ID: DTXSID10186283
• Nikkaji Number: J1.639.400I
• Wikidata: Q27279176
• Mol file: 3259-03-8.mol

Synonyms:2-(2-Ethoxyphenoxy)ethyl Bromide;3259-03-8;1-(2-Bromoethoxy)-2-ethoxybenzene;2-(2-ethoxyphenoxy)ethylbromide;Benzene, 1-(2-bromoethoxy)-2-ethoxy-;1-(2-BROMOETHOXY)-2-ETHYOXYBENZENE;MFCD02030483;GMJ3274102;2-(2-Bromoethoxy)phenetole;Benzene, 1-(2-bromoethoxy)-2-ethoxy- (7CI,8CI,9CI);2-(o-Ethoxyphenoxy)ethyl bromide;Tamsulosin Hydrochloride Impurity I;Tamsulosin Impurity I;1-(2-bromoethoxy)-2-ethoxy-benzene;ETHYL4-BORONOCINNAMATE;SCHEMBL1412326;2-(o-ethoxyphenoxy)ethylbromide;UNII-GMJ3274102;2-(o-ethoxyphenoxy)ethyl bromide;DTXSID10186283;IOYHGBZPUZBUTJ-UHFFFAOYSA-N;AMY31226;AKOS000164018;AC-5615;CS-W002871;DS-1212;SY030339;B3191;FT-0634750;EN300-93023;Q27279176;TAMSULOSIN HYDROCHLORIDE IMPURITY I [EP IMPURITY];1-(2-bromoethoxy)-2-ethoxybenzene

Chemical Property of 1-(2-Bromoethoxy)-2-ethoxybenzene

Chemical Property:

• Appearance/Colour: white solid
• Vapor Pressure: 0.00442mmHg at 25°C
• Melting Point: 41-43 °C
• Refractive Index: 1.528
• Boiling Point: 286.9 °C at 760 mmHg
• Flash Point: 119.2 °C
• PSA: 18.46000
• Density: 1.334 g/cm³
• LogP: 2.85900
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 244.00989
• Heavy Atom Count: 13
• Complexity: 130

Purity/Quality:

99% ^*data from raw suppliers

2-(2-Ethoxyphenoxy)ethylBromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: R36/37/38:Irritating to eyes, respiratory system and skin.
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=CC=C1OCCBr
• Uses: Tamsulosine intermediate

Technology Process of 1-(2-Bromoethoxy)-2-ethoxybenzene

There total 1 articles about 1-(2-Bromoethoxy)-2-ethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.1%

2-Ethoxyphenol (94-71-3) + ethylene dibromide (106-93-4) → 2-(o-ethoxyphenoxy)-ethyl bromide (3259-03-8)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; sodium hydrogencarbonate; In water; at 60 - 65 ℃; for 10h; Reagent/catalyst; Temperature; Large scale;

Reference yield: 85.0%

ethylenediamine (107-15-3,85404-18-8) + 2-(o-ethoxyphenoxy)-ethyl bromide (3259-03-8) → N?(2?(2?ethoxyphenoxy)ethyl)ethylenediamine

Guidance literature:

ethylenediamine; With lithium; at 110 ℃; for 2h; Inert atmosphere; Schlenk technique;

2-(o-ethoxyphenoxy)-ethyl bromide; In toluene; at 110 ℃; for 1h; Inert atmosphere; Schlenk technique;

DOI:10.1007/s10562-021-03561-4

Reference yield:

2-(o-ethoxyphenoxy)-ethyl bromide (3259-03-8) → (R)-tamsulosin (106133-20-4,106138-88-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; potassium iodide / water / 100 °C

2: palladium 10% on activated carbon; ammonium formate; methanol / 20 °C

With methanol; palladium 10% on activated carbon; ammonium formate; potassium iodide; sodium hydroxide; In water;

upstream raw materials:

2-Ethoxyphenol

ethylene dibromide

Downstream raw materials:

N-(thiazol-2-yl)-2-(4-(2-(4-ethoxyphenoxy)ethyl)piperazin-1-yl)acetamide

(R)-tamsarocin (-)-camphor-10-sulfonate

(S)-tamsarocin (+)-camphor-10-sulfonate

Refernces

• 1、 -. "A 2 - (2 - ethoxyphenoxy) bromo ethane industrial preparation method". Paragraph 0033; 0034; 0035. . Retrieved 2017/01/19.