9H-Purin-2-amine, 9-[2-azido-3-[(4-methoxyphenyl)diphenylmethoxy]propyl]-6-chloro-N-(tri phenylphosphoranylidene)-

Base Information

• Chemical Name: 9H-Purin-2-amine, 9-[2-azido-3-[(4-methoxyphenyl)diphenylmethoxy]propyl]-6-chloro-N-(tri phenylphosphoranylidene)-
• CAS No.: 918868-89-0
• Molecular Formula: C46H38ClN8O2P
• Molecular Weight: 801.287
• Mol file: 918868-89-0.mol

Synonyms:

Chemical Property of 9H-Purin-2-amine, 9-[2-azido-3-[(4-methoxyphenyl)diphenylmethoxy]propyl]-6-chloro-N-(tri phenylphosphoranylidene)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9H-Purin-2-amine, 9-[2-azido-3-[(4-methoxyphenyl)diphenylmethoxy]propyl]-6-chloro-N-(tri phenylphosphoranylidene)-

There total 4 articles about 9H-Purin-2-amine, 9-[2-azido-3-[(4-methoxyphenyl)diphenylmethoxy]propyl]-6-chloro-N-(tri phenylphosphoranylidene)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

(+/-)-2-azido-3-[(4-methoxytrityl)oxy]propan-1-ol (918868-72-1) + triphenylphosphine (603-35-0) + 2-Amino-6-chloropurin (10310-21-1) → C46H38ClN8O2P (918868-89-0)

Guidance literature:

With di-isopropyl azodicarboxylate; In tetrahydrofuran; at 20 ℃;

DOI:10.1135/cccc20060015

Reference yield:

benzoic acid 2-hydroxy-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-propyl ester → C46H38ClN8O2P (918868-89-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 21.43 g / pyridine / 2 h

2: NaN₃ / dimethylformamide / 100 °C

3: 7.44 g / NaOH / methanol

4: 45 percent / diisopropyl azodicarboxylate / tetrahydrofuran / 20 °C

With pyridine; sodium hydroxide; sodium azide; di-isopropyl azodicarboxylate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 4: Mitsunobu reaction;

DOI:10.1135/cccc20060015

Reference yield:

benzoic acid 2-azido-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-propyl ester → C46H38ClN8O2P (918868-89-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 7.44 g / NaOH / methanol

2: 45 percent / diisopropyl azodicarboxylate / tetrahydrofuran / 20 °C

With sodium hydroxide; di-isopropyl azodicarboxylate; In tetrahydrofuran; methanol; 2: Mitsunobu reaction;

DOI:10.1135/cccc20060015

upstream raw materials:

(+/-)-2-azido-3-[(4-methoxytrityl)oxy]propan-1-ol

triphenylphosphine

2-Amino-6-chloropurin

(+/-)-2-(mesyloxy)-3-[(4-methoxytrityl)oxy]propyl benzoate

Downstream raw materials:

(+/-)-9-{2-amino-3-[(4-methoxytrityl)oxy]propyl}-6-chloro-9H-purin-2-amine

(+/-)-9-{2-azido-3-[(4-methoxytrityl)oxy]propyl}-6-chloro-9H-purin-2-amine