N-[(1R,2S,7S,7aS)-2-Hydroxy-7-(4-methoxybenzyloxy)-5-oxohexahydro-1H-pyrrolizin-1-yl]-4,N-dimethylbenzenesulfonamide

Base Information

Chemical Name:N-[(1R,2S,7S,7aS)-2-Hydroxy-7-(4-methoxybenzyloxy)-5-oxohexahydro-1H-pyrrolizin-1-yl]-4,N-dimethylbenzenesulfonamide
CAS No.:290835-96-0
Molecular Formula:C₂₃H₂₈N₂O₆S
Molecular Weight:460.551
Hs Code.:

Synonyms:N-[(1R,2S,7S,7aS)-2-Hydroxy-7-(4-methoxybenzyloxy)-5-oxohexahydro-1H-pyrrolizin-1-yl]-4,N-dimethylbenzenesulfonamide

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Chemical Property of N-[(1R,2S,7S,7aS)-2-Hydroxy-7-(4-methoxybenzyloxy)-5-oxohexahydro-1H-pyrrolizin-1-yl]-4,N-dimethylbenzenesulfonamide

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Technology Process of N-[(1R,2S,7S,7aS)-2-Hydroxy-7-(4-methoxybenzyloxy)-5-oxohexahydro-1H-pyrrolizin-1-yl]-4,N-dimethylbenzenesulfonamide

There total 1 articles about N-[(1R,2S,7S,7aS)-2-Hydroxy-7-(4-methoxybenzyloxy)-5-oxohexahydro-1H-pyrrolizin-1-yl]-4,N-dimethylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 290835-95-9
N-[(1R,2S,7S,7aS)-2-Hydroxy-7-(4-methoxybenzyloxy)-5-oxohexahydro-1H-pyrrolizin-1-yl]-4-methylbenzenesulfonamide

: 74-88-4
methyl iodide

: 290835-96-0
N-[(1R,2S,7S,7aS)-2-Hydroxy-7-(4-methoxybenzyloxy)-5-oxohexahydro-1H-pyrrolizin-1-yl]-4,N-dimethylbenzenesulfonamide

Guidance literature:: N-[(1R,2S,7S,7aS)-2-Hydroxy-7-(4-methoxybenzyloxy)-5-oxohexahydro-1H-pyrrolizin-1-yl]-4-methylbenzenesulfonamide; With potassium tert-butylate; In tert-butyl alcohol; at 20 ℃; for 0.25h;

methyl iodide; In tert-butyl alcohol; at 50 ℃; for 16h; Further stages.;

Reference yield: 99.0%

: 124-63-0
methanesulfonyl chloride

: 290835-96-0
N-[(1R,2S,7S,7aS)-2-Hydroxy-7-(4-methoxybenzyloxy)-5-oxohexahydro-1H-pyrrolizin-1-yl]-4,N-dimethylbenzenesulfonamide

: 290835-97-1
{(1R,2S,7S,7aS)-7-(4-Methoxybenzyloxy)-1-[methyl(4-tolylsulfonyl)amino]-5-oxohexahydro-1H-pyrrolizin-2-yl} methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 0.25h;

Reference yield:

: 290835-96-0
N-[(1R,2S,7S,7aS)-2-Hydroxy-7-(4-methoxybenzyloxy)-5-oxohexahydro-1H-pyrrolizin-1-yl]-4,N-dimethylbenzenesulfonamide

: (7S)-7-Hydroxy-1-{methyl[(4-methylphenyl)sulfonyl]amino}-5,6,7,7a-tetrahydro-3H-pyrrolizine

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / Et₃N / CH₂Cl₂ / 0.25 h / 0 °C

2: BH₃*SMe₂ / tetrahydrofuran / 5 h / 20 °C

3: 15.0 mg / Pd(OH)2/C / methanol / 14 h / 20 °C

4: 70 percent / DDQ; H₂O / CH₂Cl₂ / 64 h / 20 °C

5: 70 percent / KHMDS / tetrahydrofuran; toluene / 0.33 h / 0 °C

With dimethylsulfide borane complex; water; potassium hexamethylsilazane; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium dihydroxide; In tetrahydrofuran; methanol; dichloromethane; toluene;