7-Chloro-4-ethoxy-2-methyl-5-phenylpyrido[4,3-d]pyrimidine

Base Information

Chemical Name:7-Chloro-4-ethoxy-2-methyl-5-phenylpyrido[4,3-d]pyrimidine
CAS No.:918898-07-4
Molecular Formula:C16H14ClN3O
Molecular Weight:299.76
Hs Code.:
DSSTox Substance ID:DTXSID50579978
Nikkaji Number:J2.391.266J
Wikidata:Q82470676

Synonyms:918898-07-4;7-Chloro-4-ethoxy-2-methyl-5-phenylpyrido[4,3-d]pyrimidine;DTXSID50579978

Suppliers and Price of 7-Chloro-4-ethoxy-2-methyl-5-phenylpyrido[4,3-d]pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-Chloro-4-ethoxy-2-methyl-5-phenylpyrido[4,3-d]pyrimidine

Chemical Property:

XLogP3:4.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:299.0825398
Heavy Atom Count:21
Complexity:338

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC1=NC(=NC2=CC(=NC(=C21)C3=CC=CC=C3)Cl)C

Technology Process of 7-Chloro-4-ethoxy-2-methyl-5-phenylpyrido[4,3-d]pyrimidine

There total 6 articles about 7-Chloro-4-ethoxy-2-methyl-5-phenylpyrido[4,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 929288-22-2
4-amino-2,6-dichloronicotinic acid

: 918898-07-4
7-chloro-4-ethoxy-2-methyl-5-phenyl-pyrido[4,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: SOCl₂ / 1,2-dichloro-ethane / 3 h / Heating

1.2: aq. NH₃ / diethyl ether / 0.33 h / 0 °C

2.1: 38 percent / 12 h / Heating

3.1: Pd(PPh₃)4 / dioxane / 1 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; In 1,4-dioxane; 1,2-dichloro-ethane; 3.1: Stille coupling;
DOI:10.1016/j.tetlet.2006.10.056

Reference yield:

: 501907-61-5
tert-butyl (2,6-dichloropyridin-4-yl)carbamate

: 918898-07-4
7-chloro-4-ethoxy-2-methyl-5-phenyl-pyrido[4,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-BuLi / diethyl ether / -78 - 20 °C

2.1: TFA / CH₂Cl₂ / 12 h / 20 °C

3.1: SOCl₂ / 1,2-dichloro-ethane / 3 h / Heating

3.2: aq. NH₃ / diethyl ether / 0.33 h / 0 °C

4.1: 38 percent / 12 h / Heating

5.1: Pd(PPh₃)4 / dioxane / 1 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; thionyl chloride; trifluoroacetic acid; In 1,4-dioxane; diethyl ether; dichloromethane; 1,2-dichloro-ethane; 5.1: Stille coupling;
DOI:10.1016/j.tetlet.2006.10.056

Reference yield:

: 918898-03-0
4-amino-2,6-dichloropyridine-3-carboxamide

: 918898-07-4
7-chloro-4-ethoxy-2-methyl-5-phenyl-pyrido[4,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 38 percent / 12 h / Heating

2: Pd(PPh₃)4 / dioxane / 1 h / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 2: Stille coupling;
DOI:10.1016/j.tetlet.2006.10.056