Pyrrolo[2,1-a]isoquinoline-3-carboxylic acid, 5,6-dihydro-8,9-dimethoxy-2-[5-methoxy-2,4-bis(phenylmethoxy)phenyl] -1-[4-methoxy-3-(phenylmethoxy)phenyl]-, ethyl ester

Base Information

Chemical Name:Pyrrolo[2,1-a]isoquinoline-3-carboxylic acid, 5,6-dihydro-8,9-dimethoxy-2-[5-methoxy-2,4-bis(phenylmethoxy)phenyl] -1-[4-methoxy-3-(phenylmethoxy)phenyl]-, ethyl ester
CAS No.:919082-37-4
Molecular Formula:C52H49NO9
Molecular Weight:831.962
Hs Code.:

Pyrrolo[2,1-a]isoquinoline-3-carboxylic acid,
5,6-dihydro-8,9-dimethoxy-2-[5-methoxy-2,4-bis(phenylmethoxy)phenyl]
-1-[4-methoxy-3-(phenylmethoxy)phenyl]-, ethyl ester

Synonyms:

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Chemical Property of Pyrrolo[2,1-a]isoquinoline-3-carboxylic acid, 5,6-dihydro-8,9-dimethoxy-2-[5-methoxy-2,4-bis(phenylmethoxy)phenyl] -1-[4-methoxy-3-(phenylmethoxy)phenyl]-, ethyl ester

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MSDS Files:: SDS file from LookChem

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Technology Process of Pyrrolo[2,1-a]isoquinoline-3-carboxylic acid, 5,6-dihydro-8,9-dimethoxy-2-[5-methoxy-2,4-bis(phenylmethoxy)phenyl] -1-[4-methoxy-3-(phenylmethoxy)phenyl]-, ethyl ester

There total 9 articles about Pyrrolo[2,1-a]isoquinoline-3-carboxylic acid, 5,6-dihydro-8,9-dimethoxy-2-[5-methoxy-2,4-bis(phenylmethoxy)phenyl] -1-[4-methoxy-3-(phenylmethoxy)phenyl]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 41183-13-5
1-(3-benzyloxy-4-methoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-isoquinoline

: 1034028-91-5
(Z)-ethyl 2,4-bis(benzyloxy)-5-methoxy-α-nitrocinnamate

: 919082-37-4
ethyl 1-(3-benzyloxy-4-methoxyphenyl)-2-(2,4-dibenzyloxy-5-methoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

Guidance literature:: With sodium hydrogencarbonate; In acetonitrile; for 18h; Heating;
DOI:10.1021/jo061810h

Reference yield:

: 100-39-0
benzyl bromide

: 919082-37-4
ethyl 1-(3-benzyloxy-4-methoxyphenyl)-2-(2,4-dibenzyloxy-5-methoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

2: sodium hydrogencarbonate / acetonitrile / 18 h / Heating

With sodium hydrogencarbonate; In acetonitrile;
DOI:10.1021/jo061810h

Reference yield:

: 5487-33-2
O-benzylhomoisovanillic acid

: 919082-37-4
ethyl 1-(3-benzyloxy-4-methoxyphenyl)-2-(2,4-dibenzyloxy-5-methoxyphenyl)-8,9-dimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

2: sodium carbonate / dichloromethane; water / 2 h / 20 °C

3: trichlorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C

4: sodium hydrogencarbonate / acetonitrile / 18 h / Heating

With oxalyl dichloride; sodium hydrogencarbonate; sodium carbonate; N,N-dimethyl-formamide; trichlorophosphate; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 3: Bischler-Napieralski reaction;
DOI:10.1021/jo061810h