1H-Pyrazole, 4-bromo-3,5-dimethyl-1-(triphenylmethyl)-

Base Information

Chemical Name:1H-Pyrazole, 4-bromo-3,5-dimethyl-1-(triphenylmethyl)-
CAS No.:919802-98-5
Molecular Formula:C₂₄H₂₁BrN₂
Molecular Weight:417.348
Hs Code.:

Synonyms:

Suppliers and Price of 1H-Pyrazole, 4-bromo-3,5-dimethyl-1-(triphenylmethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 3 raw suppliers

Chemical Property of 1H-Pyrazole, 4-bromo-3,5-dimethyl-1-(triphenylmethyl)-

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazole, 4-bromo-3,5-dimethyl-1-(triphenylmethyl)-

There total 1 articles about 1H-Pyrazole, 4-bromo-3,5-dimethyl-1-(triphenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 3398-16-1
4-Bromo-3,5-dimethylpyrazole

: 76-83-5
trityl chloride

: 919802-98-5
4-bromo-3,5-dimethyl-1-trityl-1H-pyrazole

Guidance literature:: With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.tetlet.2016.01.043

Reference yield:

: 919802-98-5
4-bromo-3,5-dimethyl-1-trityl-1H-pyrazole

: 14181-26-1
1,4-bis(3,5-dimethyl-1H-pyrazol-4-yl)benzene

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 - 20 °C / Inert atmosphere

1.3: 1 h / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane / 18 h / 80 °C / Inert atmosphere

3.1: trifluoroacetic acid / methanol; dichloromethane / 18 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; hexane; dichloromethane; 2.1: |Suzuki Coupling;
DOI:10.1016/j.tetlet.2016.01.043

Reference yield:

: 919802-98-5
4-bromo-3,5-dimethyl-1-trityl-1H-pyrazole

: C₁₃H₁₄N₂O₂

Guidance literature:: Multi-step reaction with 2 steps

1: tripotassium phosphate dihydrate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 18 h / 80 °C / Inert atmosphere

2: trifluoroacetic acid / methanol; dichloromethane / 18 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tripotassium phosphate dihydrate; trifluoroacetic acid; In 1,4-dioxane; methanol; dichloromethane; 1: |Suzuki Coupling;
DOI:10.1016/j.tetlet.2016.01.043