TERT-BUTYL 3,4-DIHYDRO-2HSPIRO[ ISOQUINOLINE-1,4'- PIPERIDINE]-1'-CARBOXYLATE

Base Information

• Chemical Name: TERT-BUTYL 3,4-DIHYDRO-2HSPIRO[ ISOQUINOLINE-1,4'- PIPERIDINE]-1'-CARBOXYLATE
• CAS No.: 920023-55-8
• Molecular Formula: C₁₇H₂₄N₂O₂
• Molecular Weight: 288.39
• Mol file: 920023-55-8.mol

Synonyms:tert-butyl 3,4-dihydro-2H-spiro[isoquinoline-1,4'-piperidine]-1'-carboxylate;

Chemical Property of TERT-BUTYL 3,4-DIHYDRO-2HSPIRO[ ISOQUINOLINE-1,4'- PIPERIDINE]-1'-CARBOXYLATE

Chemical Property:

• Boiling Point: 406.1±45.0 °C(Predicted)
• PKA: 8.71±0.20(Predicted)
• PSA: 41.57000
• Density: 1.15±0.1 g/cm3(Predicted)
• LogP: 3.28270

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 3,4-DIHYDRO-2HSPIRO[ ISOQUINOLINE-1,4'- PIPERIDINE]-1'-CARBOXYLATE

There total 8 articles about TERT-BUTYL 3,4-DIHYDRO-2HSPIRO[ ISOQUINOLINE-1,4'- PIPERIDINE]-1'-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1'-tert-butyloxycarbonylspiro[isoindoline-1,4'-piperidine]-3-one (920023-54-7) + dimethylsulfide borane complex (13292-87-0) → 1'-tert-butyloxycarbonylspiro[isoindoline-1,4'-piperidine] (920023-55-8)

Guidance literature:

In tetrahydrofuran; toluene; for 5h; Heating / reflux;

Reference yield: 56.0%

tert-butyl 4-(2-((4-methoxyphenyl)sulfonyl)hydrazono)piperidine-1-carboxylate (1510865-53-8) + 2-(azidomethyl)phenylboronic acid (745835-05-6) → 1'-tert-butyloxycarbonylspiro[isoindoline-1,4'-piperidine] (920023-55-8)

Guidance literature:

With lithium methanolate; In 1,4-dioxane; at 20 - 150 ℃; for 1.16667h; Inert atmosphere; Microwave irradiation; Sealed tube;

DOI:10.1002/anie.202113370

Reference yield:

1'-tert-butyloxycarbonylspiro[isoindoline-1,4'-piperidine]-3-one (920023-54-7) → 1'-tert-butyloxycarbonylspiro[isoindoline-1,4'-piperidine] (920023-55-8)

Guidance literature:

With borane-THF; In toluene; for 5h; Reflux;

upstream raw materials:

1'-tert-butyloxycarbonylspiro[isoindoline-1,4'-piperidine]-3-one

dimethylsulfide borane complex

N-tert-butyloxycarbonylpiperidin-4-one

2-Iodobenzoyl chloride