Technology Process of 1-Ethoxycarbonyl-5-methyl-(3R)-3-tert-butyl-dimethylsilyloxypentanedioate
There total 7 articles about 1-Ethoxycarbonyl-5-methyl-(3R)-3-tert-butyl-dimethylsilyloxypentanedioate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
triethylamine;
In
hexane;
at -40 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium; triphenylmethane; (1R,2S)-1-phenyl-2-(1-pyrrolidinyl)-1-propanol / toluene; hexane; tetrahydrofuran / 2 h / -78 °C
1.2: 3 h
2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate
3.1: sodium methylate / 3 h / 0 - 5 °C / Cooling with ice
3.3: pH 6.5
4.1: triethylamine / hexane / 3 h / -40 °C
With
n-butyllithium; triphenylmethane; hydrogen; sodium methylate; (1R,2S)-1-phenyl-2-(1-pyrrolidinyl)-1-propanol; triethylamine;
palladium 10% on activated carbon;
In
tetrahydrofuran; hexane; ethyl acetate; toluene;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate
2.1: sodium methylate / 3 h / 0 - 5 °C / Cooling with ice
2.3: pH 6.5
3.1: triethylamine / hexane / 3 h / -40 °C
With
hydrogen; sodium methylate; triethylamine;
palladium 10% on activated carbon;
In
hexane; ethyl acetate;