3-Pyrrolidinecarboxylic acid, 4-[[[(3R,4S)-4-[[[(3R,4S)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[(1S )-1-(4-methoxyphenyl)ethyl]-5-oxo-3-pyrrolidinyl]carbonyl]amino]-1-[(1S) -1-(4-methoxyphenyl)ethyl]-5-oxo-3-pyrrolidinyl]carbonyl]amino]-1-[(1S)- 1-(4-methoxyphenyl)ethyl]-5-oxo-, methyl ester, (3R,4S)-

Base Information

Chemical Name:3-Pyrrolidinecarboxylic acid, 4-[[[(3R,4S)-4-[[[(3R,4S)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[(1S )-1-(4-methoxyphenyl)ethyl]-5-oxo-3-pyrrolidinyl]carbonyl]amino]-1-[(1S) -1-(4-methoxyphenyl)ethyl]-5-oxo-3-pyrrolidinyl]carbonyl]amino]-1-[(1S)- 1-(4-methoxyphenyl)ethyl]-5-oxo-, methyl ester, (3R,4S)-
CAS No.:920298-32-4
Molecular Formula:C48H60N6O12
Molecular Weight:913.037
Hs Code.:

3-Pyrrolidinecarboxylic acid,
4-[[[(3R,4S)-4-[[[(3R,4S)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[(1S
)-1-(4-methoxyphenyl)ethyl]-5-oxo-3-pyrrolidinyl]carbonyl]amino]-1-[(1S)
-1-(4-methoxyphenyl)ethyl]-5-oxo-3-pyrrolidinyl]carbonyl]amino]-1-[(1S)-
1-(4-methoxyphenyl)ethyl]-5-oxo-, methyl ester, (3R,4S)-

Synonyms:

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Chemical Property of 3-Pyrrolidinecarboxylic acid, 4-[[[(3R,4S)-4-[[[(3R,4S)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[(1S )-1-(4-methoxyphenyl)ethyl]-5-oxo-3-pyrrolidinyl]carbonyl]amino]-1-[(1S) -1-(4-methoxyphenyl)ethyl]-5-oxo-3-pyrrolidinyl]carbonyl]amino]-1-[(1S)- 1-(4-methoxyphenyl)ethyl]-5-oxo-, methyl ester, (3R,4S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3-Pyrrolidinecarboxylic acid, 4-[[[(3R,4S)-4-[[[(3R,4S)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[(1S )-1-(4-methoxyphenyl)ethyl]-5-oxo-3-pyrrolidinyl]carbonyl]amino]-1-[(1S) -1-(4-methoxyphenyl)ethyl]-5-oxo-3-pyrrolidinyl]carbonyl]amino]-1-[(1S)- 1-(4-methoxyphenyl)ethyl]-5-oxo-, methyl ester, (3R,4S)-

There total 4 articles about 3-Pyrrolidinecarboxylic acid, 4-[[[(3R,4S)-4-[[[(3R,4S)-4-[[(1,1-dimethylethoxy)carbonyl]amino]-1-[(1S )-1-(4-methoxyphenyl)ethyl]-5-oxo-3-pyrrolidinyl]carbonyl]amino]-1-[(1S) -1-(4-methoxyphenyl)ethyl]-5-oxo-3-pyrrolidinyl]carbonyl]amino]-1-[(1S)- 1-(4-methoxyphenyl)ethyl]-5-oxo-, methyl ester, (3R,4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 920298-23-3
(3R,4S)-{4-(tert-butoxycarbonylamino)-1-[(1S)-1-(4-methoxyphenyl)ethyl]-5-oxopyrrolidin-3-yl}carboxylic acid

: (3R,4S)-4-({(3R,4S)-4-Amino-1-[(S)-1-(4-methoxy-phenyl)-ethyl]-5-oxo-pyrrolidine-3-carbonyl}-amino)-1-[(S)-1-(4-methoxy-phenyl)-ethyl]-5-oxo-pyrrolidine-3-carboxylic acid methyl ester; compound with trifluoro-acetic acid

: 920298-32-4
4-({4-({4-tert-butoxycarbonylamino-1-[1-(4-methoxy-phenyl)-ethyl]-5-oxo-pyrrolidine-3-carbonyl}-amino)-1-[1-(4-methoxy-phenyl)-ethyl]-5-oxo-pyrrolidine-3-carbonyl}-amino)-1-[1-(4-methoxy-phenyl)-ethyl]-5-oxo-pyrrolidine-3-carboxylic acid methyl ester

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1039/b612071g

Reference yield:

: 856410-19-0
(3S,4R,1'S)-4-methoxycarbonyl-3-trichloroacetylamino-1-[1'-(4''-methoxyphenyl)ethyl]pyrrolidin-2-one

: 920298-32-4
4-({4-({4-tert-butoxycarbonylamino-1-[1-(4-methoxy-phenyl)-ethyl]-5-oxo-pyrrolidine-3-carbonyl}-amino)-1-[1-(4-methoxy-phenyl)-ethyl]-5-oxo-pyrrolidine-3-carbonyl}-amino)-1-[1-(4-methoxy-phenyl)-ethyl]-5-oxo-pyrrolidine-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: aq.NaOH / 24 h / 20 °C

1.2: 93 percent / HCl / pH 1

2.1: triethylamine / methanol / 12 h / 20 °C

2.2: 0.36 g / diethyl ether

3.1: 90 percent / aq.NaOH / methanol / 12 h / 20 °C

4.1: 67 percent / triethylamine; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 12 h / 20 °C

With sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane;
DOI:10.1039/b612071g

Reference yield:

: 856410-14-5
methyl (3R,4S)-{4-(tert-butoxycarbonylamino)-1-[(1S)-1-(4-methoxyphenyl)ethyl]-5-oxopyrrolidin-3-yl}carboxylate

: 920298-32-4
4-({4-({4-tert-butoxycarbonylamino-1-[1-(4-methoxy-phenyl)-ethyl]-5-oxo-pyrrolidine-3-carbonyl}-amino)-1-[1-(4-methoxy-phenyl)-ethyl]-5-oxo-pyrrolidine-3-carbonyl}-amino)-1-[1-(4-methoxy-phenyl)-ethyl]-5-oxo-pyrrolidine-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / aq.NaOH / methanol / 12 h / 20 °C

2: 67 percent / triethylamine; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 12 h / 20 °C

With sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In methanol; dichloromethane;
DOI:10.1039/b612071g