3(2H)-Pyridazinone,6-[[2,6-dichloro-4-(hydroxymethyl)phenyl]methyl]-4-(1-methylethyl)-

Base Information

Chemical Name:3(2H)-Pyridazinone,6-[[2,6-dichloro-4-(hydroxymethyl)phenyl]methyl]-4-(1-methylethyl)-
CAS No.:920509-55-3
Molecular Formula:C15H16Cl2N2O2
Molecular Weight:327.21
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3(2H)-Pyridazinone,6-[[2,6-dichloro-4-(hydroxymethyl)phenyl]methyl]-4-(1-methylethyl)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 3(2H)-Pyridazinone,6-[[2,6-dichloro-4-(hydroxymethyl)phenyl]methyl]-4-(1-methylethyl)-

There total 7 articles about 3(2H)-Pyridazinone,6-[[2,6-dichloro-4-(hydroxymethyl)phenyl]methyl]-4-(1-methylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 920509-54-2
3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-ylmethyl)benzoic acid methyl ester

: 920509-55-3
6-(2,6-dichloro-4-hydroxymethylbenzyl)-4-isopropylpyridazin-3-one

Guidance literature:: 3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-ylmethyl)benzoic acid methyl ester; With diisobutylaluminium hydride; In tetrahydrofuran; at 20 - 25 ℃; for 24.5h;

With hydrogenchloride; sodium chloride; In tetrahydrofuran; water;

Reference yield:

: 20098-48-0
3,4,5-trichloronitrobenzen

: 920509-55-3
6-(2,6-dichloro-4-hydroxymethylbenzyl)-4-isopropylpyridazin-3-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 50 °C / Inert atmosphere

2.1: tin(ll) chloride; hydrogenchloride / ethanol / 110 °C / Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 60 °C / Inert atmosphere

4.1: acetic acid; hydrogenchloride / water / 24 h / 120 °C

5.1: sulfuric acid; acetic acid; sodium nitrite / water / 1 h / 20 - 60 °C

5.2: 1 h / 100 °C

6.1: palladium diacetate; 1,3-bis-(diphenylphosphino)propane; triethylamine / acetonitrile / 2.5 h / 20 - 90 °C / 2327.23 Torr / Sealed tube; Inert atmosphere

7.1: diisobutylaluminium hydride / tetrahydrofuran / 24.5 h / 20 - 25 °C / Inert atmosphere

With hydrogenchloride; sulfuric acid; 1,3-bis-(diphenylphosphino)propane; potassium tert-butylate; palladium diacetate; diisobutylaluminium hydride; potassium carbonate; acetic acid; triethylamine; tin(ll) chloride; sodium nitrite; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm4019299

Reference yield:

: 88135-30-2
2-(2,6-dichloro-4-nitrophenyl)acetonitrile

: 920509-55-3
6-(2,6-dichloro-4-hydroxymethylbenzyl)-4-isopropylpyridazin-3-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: tin(ll) chloride; hydrogenchloride / ethanol / 110 °C / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 60 °C / Inert atmosphere

3.1: acetic acid; hydrogenchloride / water / 24 h / 120 °C

4.1: sulfuric acid; acetic acid; sodium nitrite / water / 1 h / 20 - 60 °C

4.2: 1 h / 100 °C

5.1: palladium diacetate; 1,3-bis-(diphenylphosphino)propane; triethylamine / acetonitrile / 2.5 h / 20 - 90 °C / 2327.23 Torr / Sealed tube; Inert atmosphere

6.1: diisobutylaluminium hydride / tetrahydrofuran / 24.5 h / 20 - 25 °C / Inert atmosphere

With hydrogenchloride; sulfuric acid; 1,3-bis-(diphenylphosphino)propane; potassium tert-butylate; palladium diacetate; diisobutylaluminium hydride; acetic acid; triethylamine; tin(ll) chloride; sodium nitrite; In tetrahydrofuran; ethanol; water; acetonitrile;
DOI:10.1021/jm4019299