Technology Process of 1,3-Dioxane-4-acetic acid, 2-phenyl-6-[3-(phenylmethoxy)propyl]-, ethyl
ester, (2S,4S,6S)-
There total 12 articles about 1,3-Dioxane-4-acetic acid, 2-phenyl-6-[3-(phenylmethoxy)propyl]-, ethyl
ester, (2S,4S,6S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium tert-butylate;
In
tetrahydrofuran;
at 0 ℃;
DOI:10.1021/ol062595u
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 93 percent / n-BuLi / tetrahydrofuran; hexane / -78 - 0 °C
2.1: Ph3P; phenol / benzene / 12 h / 50 °C
2.2: 95 percent / MeI / diethyl ether / 12 h / Heating
3.1: K3Fe(CN)6; K2CO3; MeSO2NH2 / (DHQD)2-PHAL; OsO4 / 2-methyl-propan-2-ol; H2O / 0 °C
3.2: MeI / diethyl ether / 12 h / Heating
3.3: 27.9 g / pyridine; DMAP / CH2Cl2 / -78 - 0 °C
4.1: 90 percent / PPh3; triethylamine; HCOOH / Pd2(dba)3*CHCl3 / tetrahydrofuran / 20 °C
5.1: 59 percent / t-BuOK / tetrahydrofuran / 0 °C
With
n-butyllithium; formic acid; methanesulfonamide; potassium tert-butylate; potassium carbonate; triethylamine; triphenylphosphine; potassium hexacyanoferrate(III); phenol;
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; osmium(VIII) oxide; 1,4-bis(9-O-dihydroquinidine)phthalazine;
In
tetrahydrofuran; hexane; water; tert-butyl alcohol; benzene;
2.1: Trost isomerization / 3.1: Sharpless asymmetric dihydroxylation;
DOI:10.1021/ol062595u
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: Ph3P; phenol / benzene / 12 h / 50 °C
1.2: 95 percent / MeI / diethyl ether / 12 h / Heating
2.1: K3Fe(CN)6; K2CO3; MeSO2NH2 / (DHQD)2-PHAL; OsO4 / 2-methyl-propan-2-ol; H2O / 0 °C
2.2: MeI / diethyl ether / 12 h / Heating
2.3: 27.9 g / pyridine; DMAP / CH2Cl2 / -78 - 0 °C
3.1: 90 percent / PPh3; triethylamine; HCOOH / Pd2(dba)3*CHCl3 / tetrahydrofuran / 20 °C
4.1: 59 percent / t-BuOK / tetrahydrofuran / 0 °C
With
formic acid; methanesulfonamide; potassium tert-butylate; potassium carbonate; triethylamine; triphenylphosphine; potassium hexacyanoferrate(III); phenol;
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; osmium(VIII) oxide; 1,4-bis(9-O-dihydroquinidine)phthalazine;
In
tetrahydrofuran; water; tert-butyl alcohol; benzene;
1.1: Trost isomerization / 2.1: Sharpless asymmetric dihydroxylation;
DOI:10.1021/ol062595u
