METHYL 1-AMINO-1-CYCLOHEPTANECARBOXYLATE

Base Information

• Chemical Name: METHYL 1-AMINO-1-CYCLOHEPTANECARBOXYLATE
• CAS No.: 92398-50-0
• Molecular Formula: C9H17NO2.ClH
• Molecular Weight: 207.7
• Mol file: 92398-50-0.mol

Synonyms:methyl 1-aminocycloheptanecarboxylate hydrochloride;Cycloheptanecarboxylic acid,1-amino-,methyl ester,hydrochloride;

Chemical Property of METHYL 1-AMINO-1-CYCLOHEPTANECARBOXYLATE

Chemical Property:

• PSA: 52.32000
• LogP: 2.71340
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98.5% ^*data from raw suppliers

METHYL 1-AMINOCYCLOHEPTANECARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 1-AMINO-1-CYCLOHEPTANECARBOXYLATE

There total 5 articles about METHYL 1-AMINO-1-CYCLOHEPTANECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

methanol (67-56-1) + 1-aminocycloheptane-1-carboxylic acid (6949-77-5) → methyl 1-amino-cycloheptanecarboxylate hydrochloride (92398-50-0)

Guidance literature:

With thionyl chloride; at 25 - 30 ℃; for 1h; microwave irradiation;

Reference yield:

1-aminocycloheptane-1-carboxylic acid (6949-77-5) → methyl 1-amino-cycloheptanecarboxylate hydrochloride (92398-50-0)

Guidance literature:

With thionyl chloride; In methanol; at 20 ℃; Cooling with ice;

Reference yield:

cycloheptanone (502-42-1) → methyl 1-amino-cycloheptanecarboxylate hydrochloride (92398-50-0)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium carbonate / aq. ethanol / 55 - 60 °C

2: aq. NaOH / 72 h / Heating

3: HCl / 4 h / Heating

With ammonium carbonate; hydrogenchloride; sodium hydroxide; In ethanol;

DOI:10.1021/ja962905b

upstream raw materials:

methanol

1-aminocycloheptane-1-carboxylic acid

1,3-diaza-spiro[4.6]undecane-2,4-dione

cycloheptanone

Downstream raw materials:

2'-((4-(1-piperazinyl)phenyl)amino)spiro[cycloheptane-1,7'-pyrrolo[3,4-d]pyrimidin]-5'(6'H)-one

2'-((4-bromophenyl)amino)-spiro[cycloheptane-1,7'-pyrrolo[3,4-d]pyrimidin]-5'(6'H)-one

methyl 1-({[1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cycloheptanecarboxylate

1-(3-{2-[3-(2-hydroxy-ethyl)-phenyl]-ethoxy}-4-methoxy-benzoylamino)-cycloheptanecarboxylic acid methyl ester

Refernces

• 1、 -. "Tropane alkaloid and synthesis method thereof". Paragraph 0026; 0027; 0028. . Retrieved 2019/03/26.
• 2、 Palacin, Serge,Chin, Donovan N.,Simanek, Eric E.,MacDonald, John C.,Whitesides, George M.,McBride, Mary T.,Palmore, G. Tayhas R.. "Hydrogen-bonded tapes based on symmetrically substituted diketopiperazines: A robust structural motif for the engineering of molecular solids". . p. 11807 - 11816. Retrieved 2007/10/03.