Technology Process of 1H-Pyrazole-5-propanamide,
1-[(2,4-dichlorophenyl)methyl]-N-(hexylsulfonyl)-3-(1-methylethoxy)-
There total 8 articles about 1H-Pyrazole-5-propanamide,
1-[(2,4-dichlorophenyl)methyl]-N-(hexylsulfonyl)-3-(1-methylethoxy)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-[1-(2,4-dichlorobenzyl)-3-isopropoxy-1H-pyrazol-5-yl]propanoic acid;
With
1,1'-carbonyldiimidazole;
In
tetrahydrofuran;
Reflux;
1-hexanesulfonamide;
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran;
at 20 ℃;
DOI:10.1016/j.bmc.2011.12.008
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 15 h / 20 °C
2.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 20 °C / Cooling with ice
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C
3.2: -78 - 20 °C
4.1: sodium hydride / N,N-dimethyl-formamide / 20 °C / Cooling with ice
4.2: 0 - 20 °C
5.1: palladium 10% on activated carbon; formic acid / ethanol / 30 h / Reflux
6.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C
6.2: 15 h / 20 °C
7.1: sodium hydroxide / tetrahydrofuran; methanol / 2 h / 50 °C
8.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / Reflux
8.2: 20 °C
With
formic acid; oxalyl dichloride; palladium 10% on activated carbon; sodium hydride; diisobutylaluminium hydride; potassium carbonate; dimethyl sulfoxide; 1,1'-carbonyldiimidazole; sodium hydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
3.1: Swern oxidation / 3.2: Swern oxidation / 4.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/j.bmc.2011.12.008
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 20 °C / Cooling with ice
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C
2.2: -78 - 20 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 20 °C / Cooling with ice
3.2: 0 - 20 °C
4.1: palladium 10% on activated carbon; formic acid / ethanol / 30 h / Reflux
5.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C
5.2: 15 h / 20 °C
6.1: sodium hydroxide / tetrahydrofuran; methanol / 2 h / 50 °C
7.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / Reflux
7.2: 20 °C
With
formic acid; oxalyl dichloride; palladium 10% on activated carbon; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; 1,1'-carbonyldiimidazole; sodium hydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
2.1: Swern oxidation / 2.2: Swern oxidation / 3.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1016/j.bmc.2011.12.008
![3-[1-(2,4-dichlorobenzyl)-3-isopropoxy-1H-pyrazol-5-yl]propanoic acid](/Databaselist/images/loading.webp)
