Propanedioic acid, bis(2-phenylethyl) ester

Base Information

• Chemical Name: Propanedioic acid, bis(2-phenylethyl) ester
• CAS No.: 92778-42-2
• Molecular Formula: C19H20O4
• Molecular Weight: 312.365
• Mol file: 92778-42-2.mol

Synonyms:

Chemical Property of Propanedioic acid, bis(2-phenylethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanedioic acid, bis(2-phenylethyl) ester

There total 2 articles about Propanedioic acid, bis(2-phenylethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

malonic acid (141-82-2) + 2-phenylethanol (60-12-8) → malonic acid di(2-phenylethyl) ester (92778-42-2)

Guidance literature:

With 4-methyl-morpholine; 1-(4,6-dimethoxy-1,3,5-triazin-2-yl)-3,5-dimethylpyridin-1-ium chloride; In dichloromethane; at 20 ℃; for 6h;

DOI:10.1039/c8ob01660g

Reference yield: 87.0%

2-phenylethanol (60-12-8) + malonic acid dimethyl ester (108-59-8) → malonic acid di(2-phenylethyl) ester (92778-42-2)

Guidance literature:

With 4 A molecular sieve; tetrabutylammonium tricarbonylnitrosylferrate; In hexane; at 80 ℃; for 24h;

DOI:10.1021/ol702580a

Reference yield: 91.0%

malonic acid di(2-phenylethyl) ester (92778-42-2) → C19H18N2O4

Guidance literature:

With 4-acetamidobenzenesulfonyl azide; triethylamine; In dichloromethane; at 0 - 25 ℃; for 12h;

DOI:10.1021/jacs.1c02074

upstream raw materials:

malonic acid

2-phenylethanol

malonic acid dimethyl ester

Downstream raw materials:

malonic acid monophenethyl ester

Caffeic acid phenethyl ester

Refernces

• 1、 Yamada, Kohei,Liu, Jie,Kunishima, Munetaka. "Development of triazine-based esterifying reagents containing pyridines as a nucleophilic catalyst". supporting information. p. 6569 - 6575. Retrieved 2018/09/25.
• 2、 Xia, Chun-Nian,Hu, Wei-Xiao. "Synthesis of caffeic acid esters". . p. 332 - 334. Retrieved 2007/10/03.