2-(Methylamino)-1,2-diphenylethanol

Base Information

• Chemical Name: 2-(Methylamino)-1,2-diphenylethanol
• CAS No.: 54852-85-6
• Molecular Formula: C15H17 N O
• Molecular Weight: 227.3
• NSC Number: 182012
• DSSTox Substance ID: DTXSID00970193
• Nikkaji Number: J166.108F
• Mol file: 54852-85-6.mol

Synonyms:MDPE;N-methyl-1,2-diphenylethanolamine

Chemical Property of 2-(Methylamino)-1,2-diphenylethanol

Chemical Property:

• Vapor Pressure: 1.14E-05mmHg at 25°C
• Boiling Point: 355.5°C at 760 mmHg
• Flash Point: 113.2°C
• PSA: 32.26000
• Density: 1.096g/cm³
• LogP: 3.07160
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 227.131014166
• Heavy Atom Count: 17
• Complexity: 207

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC(C1=CC=CC=C1)C(C2=CC=CC=C2)O

Technology Process of 2-(Methylamino)-1,2-diphenylethanol

There total 68 articles about 2-(Methylamino)-1,2-diphenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.9%

C47H59ClN4O6SSi (1380213-66-0) → C20H25ClN2O (1380213-60-4) + (1R,2S)-1,2-diphenyl-2-(N-methyl)aminoethanol (550-58-3,20616-51-7,20616-52-8,46797-67-5,53176-60-6,54852-85-6,75196-48-4,90365-73-4)

Guidance literature:

C₄₇H₅₉ClN₄O₆SSi; With potassium carbonate; thiophenol; In dimethyl sulfoxide; at 23 ℃; for 3h; Inert atmosphere;

With potassium ethoxide; triethylamine tris(hydrogen fluoride); In ethanol; dimethyl sulfoxide; at 23 - 85 ℃; for 24.1h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201200387

Reference yield: 98.0%

N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]formamide (301191-47-9) → (1R,2S)-1,2-diphenyl-2-(N-methyl)aminoethanol (550-58-3,20616-51-7,20616-52-8,46797-67-5,53176-60-6,54852-85-6,75196-48-4,90365-73-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; at 0 - 23 ℃; for 22.1667h; Inert atmosphere;

DOI:10.1002/anie.201200370

Reference yield: 93.0%

(Z)-2-(methylimino)-1,2-diphenylethanone → N-methylamino-2 diphenyl-1,2 ethanol erythro (550-58-3,20616-51-7,20616-52-8,46797-67-5,53176-60-6,54852-85-6,75196-48-4,90365-73-4)

Guidance literature:

With platinum on carbon; hydrogen; In tetrahydrofuran; for 23h;

DOI:10.1021/ol402815d

upstream raw materials:

N-[(1S,2S)-2-hydroxy-1,2-diphenylethyl]formamide

(1S,2S)-2-amino-1,2-diphenylethanol

(1R,2S)-2-Amino-1,2-diphenylethanol

N-[(1S,2R)-2-hydroxy-1,2-diphenylethyl]formamide

Downstream raw materials:

3'-methyl-4',5'-diphenyl-2λ⁵-spiro[benzo[1,3,2]dioxaphosphole-2,2'-[1,3,2]oxazaphospholidine]

2,2,3,3,9-pentamethyl-7,8-diphenyl-1,4,6-trioxa-9-aza-5λ⁵-phospha-spiro[4.4]nonane

4,9-dimethyl-2,3,7,8-tetraphenyl-1,6-dioxa-4,9-diaza-5λ⁵-phospha-spiro[4.4]nonane

N-methylamino-2 diphenyl-1,2 ethanol erythro

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