4-Fluoro-6-methoxy-2-phenyl-5-(trifluoromethyl)pyrimidine

Base Information

Chemical Name:4-Fluoro-6-methoxy-2-phenyl-5-(trifluoromethyl)pyrimidine
CAS No.:92983-83-0
Molecular Formula:C12H8F4N2O
Molecular Weight:272.202
Hs Code.:
DSSTox Substance ID:DTXSID50575298
Wikidata:Q82464623

Synonyms:4-Fluoro-6-methoxy-2-phenyl-5-(trifluoromethyl)pyrimidine;92983-83-0;SCHEMBL11036785;DTXSID50575298;HTHGARSKAGVOPZ-UHFFFAOYSA-N

Suppliers and Price of 4-Fluoro-6-methoxy-2-phenyl-5-(trifluoromethyl)pyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Fluoro-6-methoxy-2-phenyl-5-(trifluoromethyl)pyrimidine

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:272.05727553
Heavy Atom Count:19
Complexity:294

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C(=NC(=N1)C2=CC=CC=C2)F)C(F)(F)F

Technology Process of 4-Fluoro-6-methoxy-2-phenyl-5-(trifluoromethyl)pyrimidine

There total 3 articles about 4-Fluoro-6-methoxy-2-phenyl-5-(trifluoromethyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 360-53-2
1,3,3,3-tetrafluoro-1-methoxy-2-trifluoromethyl-propene

: 1670-14-0
benzamidine monohydrochloride

: 92983-83-0
2-phenyl-4-fluoro-5-trifluoromethyl-6-methoxypyrimidine

Guidance literature:: With sodium hydroxide; In dichloromethane; for 0.5h; Ambient temperature;
DOI:10.1016/S0022-1139(00)84991-X

Reference yield: 92.0%

: 382-26-3
1,1,1,3,3-pentafluoro-3-methoxy-2-trifluoromethylpropane

: 1670-14-0
benzamidine monohydrochloride

: 92983-83-0
2-phenyl-4-fluoro-5-trifluoromethyl-6-methoxypyrimidine

Guidance literature:: With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1016/S0022-1139(00)84991-X

Reference yield:

: 382-26-3
1,1,1,3,3-pentafluoro-3-methoxy-2-trifluoromethylpropane

: 92983-83-0
2-phenyl-4-fluoro-5-trifluoromethyl-6-methoxypyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / CaOH, benzyltriethylammonium chloride / H₂O

2: 98 percent / aq. sodium hydroxide / CH₂Cl₂ / 0.5 h / Ambient temperature

With calcium hydroxide; sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In dichloromethane; water;
DOI:10.1016/S0022-1139(00)84991-X