Acetic acid, [2-(phenylmethoxy)ethoxy]-

Base Information

• Chemical Name: Acetic acid, [2-(phenylmethoxy)ethoxy]-
• CAS No.: 93206-09-8
• Molecular Formula: C11H14O4
• Molecular Weight: 210.23
• Hs Code.: 2918999090
• Mol file: 93206-09-8.mol

Synonyms:7-phenyl-3,6-dioxaheptanoic acid;

Chemical Property of Acetic acid, [2-(phenylmethoxy)ethoxy]-

Chemical Property:

• PSA: 55.76000
• LogP: 1.30440

Purity/Quality:

97% ^*data from raw suppliers

2-[2-(Benzyloxy)ethoxy]aceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Benzyl-PEG2-CH2CO2H is a PEG linker with a benzyl protecting group and a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The benzyl protecting group can be removed via hydrogenolysis. The hydrophilic PEG linker increases the water solubility of the compound.

Technology Process of Acetic acid, [2-(phenylmethoxy)ethoxy]-

There total 9 articles about Acetic acid, [2-(phenylmethoxy)ethoxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(2-(benzyloxy)ethoxy)acetic acid tert-butyl ester (1309451-06-6) → <2-(benzyloxy)ethoxy>acetic acid (93206-09-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield: 95.0%

<2-(benzyloxy)ethoxy>acetic acid methylester (93206-15-6) → <2-(benzyloxy)ethoxy>acetic acid (93206-09-8)

Guidance literature:

With methanol; potassium hydroxide; at 35 ℃; for 1h;

DOI:10.1021/bc100202y

Reference yield: 93.0%

2-(2-benzyloxyethoxy)propionic acid (124251-97-4) → <2-(benzyloxy)ethoxy>acetic acid (93206-09-8)

Guidance literature:

2-(2-benzyloxyethoxy)propionic acid; With water; lithium hydroxide; In 1,4-dioxane; at 80 ℃; for 1h;

With hydrogenchloride; In 1,4-dioxane; water;

upstream raw materials:

diethylene glycol monobenzyl ether

2-Benzyloxyethanol

chloroacetic acid

sodium 2-bromoacetate

Downstream raw materials:

2-(2-benzyloxyethoxy)acetyl chloride

2-(2-Benzyloxy-ethoxy)-N-(2-{2-[2-(2-benzyloxy-ethoxy)-acetylamino]-phenoxy}-phenyl)-acetamide

N-Benzyl-N-[2-(2-{benzyl-[2-(2-benzyloxy-ethoxy)-acetyl]-amino}-phenoxy)-phenyl]-2-(2-benzyloxy-ethoxy)-acetamide

methyl trans-4-({[2-(2-benzyloxy)ethoxy]acetyl}amino)cyclohexanecarboxylate