124251-97-4

Upstream product

• 10009-70-8 R-(+)-2-bromopropionic acid 
• 622-08-2 2-Benzyloxyethanol 
• 96-32-2 bromoacetic acid methyl ester 
• 32644-15-8 (S)-2-bromopropanoic acid 

Downstream Products

• 93206-09-8 <2-(benzyloxy)ethoxy>acetic acid 
• 123990-85-2 3-(2-Benzyloxy-ethoxy)-1-diazo-butan-2-one 
• 123990-91-0 (2R,5S)-5-Benzyloxymethyl-2-methyl-dihydro-furan-3-one 
• 123990-91-0 (2S,5S)-5-Benzyloxymethyl-2-methyl-dihydro-furan-3-one 
• 2303-35-7 (+)-muscarine chloride 
• 75499-91-1 2,5-anhydro-1,4-dideoxy-6-O-(p-tolylsulphonyl)-D-ribo-hexitol 
• 124251-98-5 (S)-3-(2-Benzyloxy-ethoxy)-1-diazo-butan-2-one 
• 123990-91-0 (S)-5-Benzyloxymethyl-2-methyl-dihydro-furan-3-one 
• 75499-86-4 (2S,3S,5R)-5-Hydroxymethyl-2-methyl-tetrahydro-furan-3-ol 

Relevant academic research and scientific papers

BENZYL-SUBSTITUTED TETRACYCLIC HETEROCYCLIC COMPOUNDS

The present invention pertains to Benzyl-substituted tetracyclic heterocyclic compounds of formula (I), as well as the resulting pharmaceutical compositions, and their use in the treatment or prophylaxis of diseases alleviated by inhibition of type 5 phosphodiesterases. Furthermore, the present invention pertains to the methods of manufacturing these Benzyl -substituted tetracyclic heterocyclic compounds.

The stereoselective synthesis of aziridine analogues of diaminopimelic acid (DAP) and their interaction with dap epimerase

Aziridine analogues of diaminopimelic acid (DAP) have been prepared stereoselectively for the first time and evaluated as inhibitors of DAP epimerase. (2R,3S,3′S)-3-(3′-Aminopropane)aziridine-2,3′- dicarboxylate 4 was synthesised and shown to be a reversible inhibitor of DAP epimerase with an IC50 value of 2.88 mM. (2S,4S)- and (2S,4R)-2-(4-Amino-4-carboxybutyl)aziridine-2-carboxylic acid (LL-azi-DAP 14 and DL-azi-DAP 29) were made as pure diastereomers, and both were shown to be irreversible inhibitors of DAP epimerase. LL-Azi-DAP 14 selectively binds to Cys-73 of the enzyme active site whereas DL-azi-DAP 29 binds to Cys-217 via attack of sulfhydryl on the methylene of the inhibitor aziridine ring. These observations are consistent with the two base mechanism proposed for the epimerisation of LL-DAP 1 and meso-DAP 2 by DAP epimerase. The Royal Society of Chemistry 2005.