(2E)-3-(4-methylphenyl)acrylic acid(SALTDATA: FREE)

Base Information

• Chemical Name: (2E)-3-(4-methylphenyl)acrylic acid(SALTDATA: FREE)
• CAS No.: 940-61-4
• Molecular Formula: C₁₀H₁₀O₂
• Molecular Weight: 162.188
• Mol file: 940-61-4.mol

Synonyms:

Chemical Property of (2E)-3-(4-methylphenyl)acrylic acid(SALTDATA: FREE)

Chemical Property:

• PSA: 37.30000
• LogP: 2.09280
• Storage Temp.: 2-8°C

Purity/Quality:

98.5% ^*data from raw suppliers

(E)-3-(4-Methylphenyl)-2-propenoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2E)-3-(4-methylphenyl)acrylic acid(SALTDATA: FREE)

There total 103 articles about (2E)-3-(4-methylphenyl)acrylic acid(SALTDATA: FREE) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(1-nosyl-5-nitroindol-3-yl)methyl (E)-3-(4-methylphenyl)prop-2-enoate → trans-p-methylcinnamic acid (1866-39-3,940-61-4)

Guidance literature:

(1-nosyl-5-nitroindol-3-yl)methyl (E)-3-(4-methylphenyl)prop-2-enoate; With 2-(N,N-dimethylamino)ethylthiol hydrochloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃; for 0.25h; Inert atmosphere;

With hydrogenchloride; In diethyl ether; water; acetonitrile; Inert atmosphere;

DOI:10.1021/ol8008655

Reference yield: 99.0%

carbon monoxide (201230-82-2) + 2-bromo-1-(4-methylphenyl)ethylene (60655-80-3) → trans-p-methylcinnamic acid (1866-39-3,940-61-4)

Guidance literature:

With [bmim]PF₆; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In water; at 100 ℃; for 30h; under 15001.2 Torr;

DOI:10.1021/jo052651p

Reference yield: 98.0%

malonic acid (141-82-2) + 4-methyl-benzaldehyde (104-87-0) → trans-p-methylcinnamic acid (1866-39-3,940-61-4)

Guidance literature:

With ammonium acetate; for 0.05h; Irradiation;

upstream raw materials:

acetic anhydride

4-methyl-benzaldehyde

2-Iodo-3-p-tolyl-propionic acid methyl ester

para-bromotoluene

Downstream raw materials:

[4-(3-p-Tolyl-propionylamino)-phenoxy]-acetic acid

ethyl 3-chloro-6-methylbenzo[b]thiophene-2-carboxylate