alpha, oMega-Dipropionic acid hexaethylene glycol

Base Information

• Chemical Name: alpha, oMega-Dipropionic acid hexaethylene glycol
• CAS No.: 94376-75-7
• Molecular Formula: C18H34O11
• Molecular Weight: 426.461
• Mol file: 94376-75-7.mol

Synonyms:α,ω-Dipropionic acid hexaethylene glycol;Alpha,ω-dipropionic acid hexaethylene glycol;HOOCCH2CH2-PEG6-CH2CH2COOH;

Chemical Property of alpha, oMega-Dipropionic acid hexaethylene glycol

Chemical Property:

• PSA: 139.21000
• LogP: 0.05200

Purity/Quality:

98%,99%, ^*data from raw suppliers

α,ω-dipropionicacidhexaethyleneglycol min.95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Bis-PEG7-acid is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Technology Process of alpha, oMega-Dipropionic acid hexaethylene glycol

There total 4 articles about alpha, oMega-Dipropionic acid hexaethylene glycol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,11-dichloro-3,6,9-trioxaundecane (638-56-2,27252-69-3) → 3-(2-{2-[2-(2-{2-[2-(2-Carboxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}-ethoxy)propionic acid (94376-75-7)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium hydroxide / 48 h / 80 °C

2: potassium hydroxide / benzene / 1 h / Ambient temperature

3: 12M hydrochloric acid / 0.08 h / Heating

With hydrogenchloride; potassium hydroxide; potassium hydroxide; In benzene;

DOI:10.1246/bcsj.61.2443

Reference yield:

pentaethylene glycol (2615-15-8) → 3-(2-{2-[2-(2-{2-[2-(2-Carboxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}-ethoxy)propionic acid (94376-75-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / benzene / 1 h / Ambient temperature

2: 12M hydrochloric acid / 0.08 h / Heating

With hydrogenchloride; potassium hydroxide; In benzene;

DOI:10.1246/bcsj.61.2443

Reference yield:

4,7,10,13,16,19,22-heptaoxapentacosanedinitrile (41263-80-3) → 3-(2-{2-[2-(2-{2-[2-(2-Carboxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}-ethoxy)propionic acid (94376-75-7)

Guidance literature:

With hydrogenchloride; for 0.0833333h; Heating;

DOI:10.1246/bcsj.61.2443

upstream raw materials:

4,7,10,13,16,19,22-heptaoxapentacosanedinitrile

1,11-dichloro-3,6,9-trioxaundecane

pentaethylene glycol

Downstream raw materials:

3-[2-(2-{2-[2-(2-{2-[2-(4-{2-[2-(2-methyl-[1,3]dioxolan-2-ylmethyl)-[1,3]dioxolan-2-yl]-ethyl}-phenylcarbamoyl)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-propionic acid

(IESDV)₂PEG₆

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