Pyrrolidine, 1-[2-(3-methoxy-2-nitrophenyl)ethenyl]-

Base Information

• Chemical Name: Pyrrolidine, 1-[2-(3-methoxy-2-nitrophenyl)ethenyl]-
• CAS No.: 96096-68-3
• Molecular Formula: C13H16N2O3
• Molecular Weight: 248.282
• Mol file: 96096-68-3.mol

Synonyms:

Chemical Property of Pyrrolidine, 1-[2-(3-methoxy-2-nitrophenyl)ethenyl]-

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(2-(3-METHOXY-2-NITRO-PHENYL)-VINYL)-PYRROLIDINE AldrichCPR ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrrolidine, 1-[2-(3-methoxy-2-nitrophenyl)ethenyl]-

There total 1 articles about Pyrrolidine, 1-[2-(3-methoxy-2-nitrophenyl)ethenyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

pyrrolidine (123-75-1) + 1-methoxy-3-methyl-2-nitro-benzene (5345-42-6) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → β-pyrrolidino-2-nitro-3-methoxystyrene (96096-68-3)

Guidance literature:

In N,N-dimethyl-formamide; at 130 ℃; for 3h;

DOI:10.1021/jm00145a007

Reference yield: 50.0%

β-pyrrolidino-2-nitro-3-methoxystyrene (96096-68-3) → 7-methoxy-1H-indole (3189-22-8)

Guidance literature:

With hydrazine hydrate; nickel; In tetrahydrofuran; methanol; at 60 ℃; for 1h;

DOI:10.1021/jm00145a007

Reference yield:

β-pyrrolidino-2-nitro-3-methoxystyrene (96096-68-3) → N-(benzyloxycarbonyl)-7-methoxytryptamine (96096-67-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 50 percent / hydrazine hydrate / Raney nickel / methanol; tetrahydrofuran / 1 h / 60 °C

2: 50 percent / tert-butylcatechol / xylene / 3 h / Heating

3: 95 percent / H₂ / 10 percent Pd/C / ethanol / 12 h / 2585.7 Torr

4: 72 percent / K₂CO₃ / H₂O; toluene / 15 h / Ambient temperature

With 3-tert-butylbenzene-1,2-diol; hydrogen; potassium carbonate; hydrazine hydrate; palladium on activated charcoal; nickel; In tetrahydrofuran; methanol; ethanol; water; toluene; xylene;

DOI:10.1021/jm00145a007

upstream raw materials:

pyrrolidine

1-methoxy-3-methyl-2-nitro-benzene

N,N-dimethyl-formamide dimethyl acetal

Downstream raw materials:

7-methoxy-1H-indole

2-(7-methoxy-indol-3-yl)-ethylamine

N-(benzyloxycarbonyl)-7-methoxytryptamine

Refernces