4-(Tert-butyldimethylsilyloxy)piperidine

Base Information

• Chemical Name: 4-(Tert-butyldimethylsilyloxy)piperidine
• CAS No.: 97231-91-9
• Molecular Formula: C11H25NOSi
• Molecular Weight: 215.411
• European Community (EC) Number: 819-912-2
• DSSTox Substance ID: DTXSID80467253
• Nikkaji Number: J1.954.309I
• Wikidata: Q82294076
• Mol file: 97231-91-9.mol

Synonyms:4-(TERT-BUTYLDIMETHYLSILYLOXY)PIPERIDINE;97231-91-9;4-[(tert-Butyldimethylsilyl)oxy]piperidine;tert-butyl-dimethyl-piperidin-4-yloxysilane;4-((tert-butyldimethylsilyl)oxy)piperidine;Piperidine, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-;4-(tert-butyldimethylsiloxy)piperidine;tert-butyl-dimethyl-(4-piperidyloxy)silane;SCHEMBL1056665;DTXSID80467253;GCPNPVFWMHBPNS-UHFFFAOYSA-N;MFCD11847779;4-(tert-butyldimethylsilyl)oxypiperidine;4-tert-butyl-dimethylsilyloxy-piperidine;4-((tert-butyldimethylsilyl)oxy)piperdine;4-(tert-butyl dimethylsilyl)oxypiperidine;4-(O-tert-butyldimethylsilyloxy)piperidine;4-((tert-butyldimethylsilyl)oxy) piperdine;4-(tert-butyl-dimethylsilanyloxy)piperidine;4-(tert-Butyl-dimethyl-silyloxy)-piperidine;4-{[tert-butyl(dimethyl)silyl]oxy}piperidine;EN300-250683;A1-08273

Chemical Property of 4-(Tert-butyldimethylsilyloxy)piperidine

Chemical Property:

• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 215.170540955
• Heavy Atom Count: 14
• Complexity: 180

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)[Si](C)(C)OC1CCNCC1

Technology Process of 4-(Tert-butyldimethylsilyloxy)piperidine

There total 1 articles about 4-(Tert-butyldimethylsilyloxy)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C21H29F6NO3Si (1448041-78-8) → 4-(tert-butyldimethylsilyloxy)piperidine (97231-91-9) + 3,5-bis(trifluoromethyl)benzylchloride (75462-61-2)

Guidance literature:

With samarium diiodide; water; triethylamine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1039/c3cc41642a

Reference yield: 98.0%

4-chloro-3-(chlorosulfonyl)benzoic acid (2494-79-3) + 4-(tert-butyldimethylsilyloxy)piperidine (97231-91-9) → C18H28ClNO5SSi

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Concentration;

Reference yield: 74.0%

6-bromo-2-cyclopropyl-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazoline + 4-(tert-butyldimethylsilyloxy)piperidine (97231-91-9) → 6-[4-(tert-butyl-dimethylsilanyloxy)piperidin-1-yl]-2-cyclopropyl-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazoline

Guidance literature:

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In toluene; Reflux; Inert atmosphere;

upstream raw materials:

C₂₁H₂₉F₆NO₃Si

Downstream raw materials:

ethyl 2-fluoro-3-(4-hydroxypiperidin-1-yl)benzoate

4-(tert-butyl-dimethyl-silanyloxy)-piperidine-1-carboxylic acid 4-(7-isopropoxy-5,6-dimethoxy-4-oxo-4H-chromen-2-ylsulfanyl)-phenyl ester

4-{2-[4-(3-fluoro-5-trifluoromethyl-phenoxy)-piperidin-1-yl]-2-oxo-ethylamino}-2-methyl-2H-pyridazin-3-one

tert-butyl 2-(2-(benzyloxy)-5-(4-hydroxypiperidin-1-yl)benzamido)-4-phenylbenzoate