tert-butyl 2-(2-(benzyloxy)-5-(4-hydroxypiperidin-1-yl)benzamido)-4-phenylbenzoate

Base Information

Chemical Name:tert-butyl 2-(2-(benzyloxy)-5-(4-hydroxypiperidin-1-yl)benzamido)-4-phenylbenzoate
CAS No.:1237519-58-2
Molecular Formula:C₃₆H₃₈N₂O₅
Molecular Weight:578.708
Hs Code.:

Synonyms:tert-butyl 2-(2-(benzyloxy)-5-(4-hydroxypiperidin-1-yl)benzamido)-4-phenylbenzoate

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Chemical Property of tert-butyl 2-(2-(benzyloxy)-5-(4-hydroxypiperidin-1-yl)benzamido)-4-phenylbenzoate

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Technology Process of tert-butyl 2-(2-(benzyloxy)-5-(4-hydroxypiperidin-1-yl)benzamido)-4-phenylbenzoate

There total 3 articles about tert-butyl 2-(2-(benzyloxy)-5-(4-hydroxypiperidin-1-yl)benzamido)-4-phenylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1237519-57-1
tert-butyl 2-(2-(benzyloxy)-5-(4-(tert-butyldimethylsilyloxy)piperidin-1-yl)benzamido)-4-phenylbenzoate

: 1237519-58-2
tert-butyl 2-(2-(benzyloxy)-5-(4-hydroxypiperidin-1-yl)benzamido)-4-phenylbenzoate

Guidance literature:: tert-butyl 2-(2-(benzyloxy)-5-(4-(tert-butyldimethylsilyloxy)piperidin-1-yl)benzamido)-4-phenylbenzoate; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 5h;

With water; In tetrahydrofuran; Cooling with ice;

Reference yield:

: 97231-91-9
4-(tert-butyldimethylsilyloxy)piperidine

: 1237519-58-2
tert-butyl 2-(2-(benzyloxy)-5-(4-hydroxypiperidin-1-yl)benzamido)-4-phenylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / palladium diacetate; XPhos / toluene / 4.5 h / Reflux; Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 20 °C

2.2: Cooling with ice

With tetrabutyl ammonium fluoride; caesium carbonate; palladium diacetate; XPhos; In tetrahydrofuran; toluene;

Reference yield:

: 1237514-90-7
tert-butyl 2-(2-(benzyloxy)-5-bromobenzamido)-4-phenylbenzoate

: 1237519-58-2
tert-butyl 2-(2-(benzyloxy)-5-(4-hydroxypiperidin-1-yl)benzamido)-4-phenylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / palladium diacetate; XPhos / toluene / 4.5 h / Reflux; Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 20 °C

2.2: Cooling with ice

With tetrabutyl ammonium fluoride; caesium carbonate; palladium diacetate; XPhos; In tetrahydrofuran; toluene;