Benzenamine, 4-[(tetrahydro-2H-pyran-2-yl)oxy]-

Base Information

• Chemical Name: Benzenamine, 4-[(tetrahydro-2H-pyran-2-yl)oxy]-
• CAS No.: 97389-23-6
• Molecular Formula: C11H15NO2
• Molecular Weight: 193.246
• DSSTox Substance ID: DTXSID90443700
• Nikkaji Number: J2.504.041D
• Mol file: 97389-23-6.mol

Synonyms:4-((tetrahydro-2H-pyran-2-yl)oxy)aniline;97389-23-6;4-[(Tetrahydro-2H-pyran-2-yl)oxy]aniline;Benzenamine, 4-[(tetrahydro-2H-pyran-2-yl)oxy]-;SCHEMBL16147809;DTXSID90443700;YKDYSZGTIRIDCC-UHFFFAOYSA-N;MFCD20691490;4-(Tetrahydro-2H-pyran-2-yloxy)aniline;SY297032

Chemical Property of Benzenamine, 4-[(tetrahydro-2H-pyran-2-yl)oxy]-

Chemical Property:

• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 193.110278721
• Heavy Atom Count: 14
• Complexity: 167

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CCOC(C1)OC2=CC=C(C=C2)N

Technology Process of Benzenamine, 4-[(tetrahydro-2H-pyran-2-yl)oxy]-

There total 9 articles about Benzenamine, 4-[(tetrahydro-2H-pyran-2-yl)oxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

tetrahydro-2H-2-pyranol (694-54-2) + 4-amino-phenol (123-30-8) → 4-[(2-tetrahydropyranyloxy)methyl]aniline (97389-23-6)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1055/s-2005-918916

Reference yield: 67.0%

→ 4-[(2-tetrahydropyranyloxy)methyl]aniline (97389-23-6)

Guidance literature:

With magnesium; ethylene dibromide; In tetrahydrofuran; Inert atmosphere;

With C₁₀H₁₇NO; In tetrahydrofuran; toluene; at -78 ℃; for 2h; Inert atmosphere;

Reference yield: 17.0%

3,4-dihydro-2H-pyran (110-87-2) + 4-amino-phenol (123-30-8) → 4-[(2-tetrahydropyranyloxy)methyl]aniline (97389-23-6)

Guidance literature:

With ruthenium(III) acetate; at 20 ℃; for 48h;

DOI:10.1139/V06-137

upstream raw materials:

2-(4-nitrophenoxy)tetrahydropyran

tetrahydro-2H-2-pyranol

4-amino-phenol

3,4-dihydro-2H-pyran

Downstream raw materials:

N-(4-hydroxyphenyl)-2,4-dimethoxybenzamide

((S)-2-tert-Butoxycarbonylamino-propionylamino)-acetic acid 4-benzyloxycarbonylamino-phenyl ester

((R)-2-tert-Butoxycarbonylamino-propionylamino)-acetic acid 4-benzyloxycarbonylamino-phenyl ester

(S)-2-tert-Butoxycarbonylamino-propionic acid 4-benzyloxycarbonylamino-phenyl ester