((S)-2-tert-Butoxycarbonylamino-propionylamino)-acetic acid 4-benzyloxycarbonylamino-phenyl ester

Base Information

Chemical Name:((S)-2-tert-Butoxycarbonylamino-propionylamino)-acetic acid 4-benzyloxycarbonylamino-phenyl ester
CAS No.:174359-53-6
Molecular Formula:C₂₄H₂₉N₃O₇
Molecular Weight:471.51
Hs Code.:

Synonyms:((S)-2-tert-Butoxycarbonylamino-propionylamino)-acetic acid 4-benzyloxycarbonylamino-phenyl ester

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Chemical Property of ((S)-2-tert-Butoxycarbonylamino-propionylamino)-acetic acid 4-benzyloxycarbonylamino-phenyl ester

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Technology Process of ((S)-2-tert-Butoxycarbonylamino-propionylamino)-acetic acid 4-benzyloxycarbonylamino-phenyl ester

There total 5 articles about ((S)-2-tert-Butoxycarbonylamino-propionylamino)-acetic acid 4-benzyloxycarbonylamino-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 7107-59-7
4-(N-Benzyloxycarbonylamino)phenol

: 28782-78-7
N-(tert-butyloxycarbonyl)-(S)-alanylglycine

: 174359-53-6
((S)-2-tert-Butoxycarbonylamino-propionylamino)-acetic acid 4-benzyloxycarbonylamino-phenyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 0 ℃; for 1h;
DOI:10.1248/cpb.43.2082

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 174359-53-6
((S)-2-tert-Butoxycarbonylamino-propionylamino)-acetic acid 4-benzyloxycarbonylamino-phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / TsOH*H₂O / benzene / 0.5 h / 60 °C

2: H₂ / 10percent Pd/C / ethanol / 20 h / Ambient temperature

3: CHCl₃ / 2 h / Ambient temperature

4: 97 percent / TsOH*H₂O / methanol / 1 h / Heating

5: 90 percent / DMAP, DCC / CH₂Cl₂; dimethylformamide / 1 h / 0 °C

With dmap; hydrogen; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; benzene;
DOI:10.1248/cpb.43.2082

Reference yield:

: 20443-91-8
2-(4-nitrophenoxy)tetrahydropyran

: 174359-53-6
((S)-2-tert-Butoxycarbonylamino-propionylamino)-acetic acid 4-benzyloxycarbonylamino-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / 10percent Pd/C / ethanol / 20 h / Ambient temperature

2: CHCl₃ / 2 h / Ambient temperature

3: 97 percent / TsOH*H₂O / methanol / 1 h / Heating

4: 90 percent / DMAP, DCC / CH₂Cl₂; dimethylformamide / 1 h / 0 °C

With dmap; hydrogen; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1248/cpb.43.2082