(6S)-6-benzyl-4,7-diazaspiro[2.5]octane-5,8-dione

Base Information

Chemical Name:(6S)-6-benzyl-4,7-diazaspiro[2.5]octane-5,8-dione
CAS No.:98735-80-9
Molecular Formula:C13H14N2O2
Molecular Weight:230.26200
Hs Code.:
DSSTox Substance ID:DTXSID301198322

Synonyms:98735-80-9;(6S)-6-benzyl-4,7-diazaspiro[2.5]octane-5,8-dione;(S)-6-Benzyl-4,7-diazaspiro[2.5]octane-5,8-dione;DTXSID301198322;AKOS030545188;F2147-8230;(6S)-6-(Phenylmethyl)-4,7-diazaspiro[2.5]octane-5,8-dione

Suppliers and Price of (6S)-6-benzyl-4,7-diazaspiro[2.5]octane-5,8-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of (6S)-6-benzyl-4,7-diazaspiro[2.5]octane-5,8-dione

Chemical Property:

PSA：58.20000
LogP:1.03390
XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:230.105527694
Heavy Atom Count:17
Complexity:343

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CC12C(=O)NC(C(=O)N2)CC3=CC=CC=C3
Isomeric SMILES:C1CC12C(=O)N[C@H](C(=O)N2)CC3=CC=CC=C3

Technology Process of (6S)-6-benzyl-4,7-diazaspiro[2.5]octane-5,8-dione

There total 6 articles about (6S)-6-benzyl-4,7-diazaspiro[2.5]octane-5,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 191033-48-4
N-Cbz-(S)-phenylalanine-(S)-cyclopropanecarboxylic acid methyl ester

: 98735-80-9
(S)-6-benzyl-4,7-diazaspiro[2,5]octane-5,8-dione

Guidance literature:: With hydrogen; palladium on activated charcoal; Yield given. Multistep reaction; 1.) MeOH, room temperature, 2 MPa, 20 min, 2.) MeOH, room temperature, 2 h.;
DOI:10.1135/cccc19970941

Reference yield:

: 1161-13-3
N-Cbz-L-Phe

: 98735-80-9
(S)-6-benzyl-4,7-diazaspiro[2,5]octane-5,8-dione

Guidance literature:: Multi-step reaction with 4 steps

1: N-methylmorpholine / dimethylformamide; tetrahydrofuran / 0.25 h / 0 °C

2: 946 mg / dimethylformamide; tetrahydrofuran / 0.75 h

3: H₂ / Pd/C / methanol / 760.05 Torr

4: 24 mg / toluene / Heating

With 4-methyl-morpholine; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1039/b303348a

Reference yield:

: 41518-17-6
Z-Phe-O-COO-isoBu

: 98735-80-9
(S)-6-benzyl-4,7-diazaspiro[2,5]octane-5,8-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 946 mg / dimethylformamide; tetrahydrofuran / 0.75 h

2: H₂ / Pd/C / methanol / 760.05 Torr

3: 24 mg / toluene / Heating

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1039/b303348a