Cyclohexanecarboxylic acid, 2-oxo-, 1-methylethyl ester

Base Information

• Chemical Name: Cyclohexanecarboxylic acid, 2-oxo-, 1-methylethyl ester
• CAS No.: 98969-09-6
• Molecular Formula: C10H16O3
• Molecular Weight: 184.235
• Mol file: 98969-09-6.mol

Synonyms:

Chemical Property of Cyclohexanecarboxylic acid, 2-oxo-, 1-methylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclohexanecarboxylic acid, 2-oxo-, 1-methylethyl ester

There total 2 articles about Cyclohexanecarboxylic acid, 2-oxo-, 1-methylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Heptanedioic acid diisopropyl ester (71340-47-1) → isopropyl 2-oxo cyclohexanecarboxylate (98969-09-6)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃;

DOI:10.1055/s-0036-1590869

Reference yield:

heptanedioic acid (111-16-0) → isopropyl 2-oxo cyclohexanecarboxylate (98969-09-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 4 h / Reflux

2: sodium hydride / mineral oil; tetrahydrofuran / 20 °C

With sulfuric acid; sodium hydride; In tetrahydrofuran; mineral oil;

DOI:10.1055/s-0036-1590869

Reference yield: 96.0%

chloro-trimethyl-silane (75-77-4) + isopropyl 2-oxo cyclohexanecarboxylate (98969-09-6) → 3-[isopropoxy(trimethylsilyloxy)methylidene]-2-trimethylsilyloxycyclohex-1-ene

Guidance literature:

isopropyl 2-oxo cyclohexanecarboxylate; With lithium diisopropyl amide; In tetrahydrofuran; at 0 ℃; for 1.5h;

chloro-trimethyl-silane; In tetrahydrofuran; at 0 ℃; for 2h; Further stages.;

DOI:10.1021/ol006419b

upstream raw materials:

heptanedioic acid

Heptanedioic acid diisopropyl ester

Downstream raw materials:

isopropyl 2-(1-pyrrolidinyl) 2-cyclohexenecarboxylate

isopropyl 2-(1-pyrrolidinyl) 1-cyclohexenecarboxylate

isopropyl 2-(1-piperidinyl) 2-cyclohexenecarboxylate

isopropyl 2-(1-piperidinyl) 1-cyclohexenecarboxylate