2-(2-Aminoethylamino)-pyridine dihydrochloride

Base Information

• Chemical Name: 2-(2-Aminoethylamino)-pyridine dihydrochloride
• CAS No.: 99669-44-0
• Molecular Formula: C₇H₁₁N₃*2ClH
• Molecular Weight: 210.106
• Hs Code.: 2933399090
• European Community (EC) Number: 674-681-3
• DSSTox Substance ID: DTXSID40557806
• Mol file: 99669-44-0.mol

Synonyms:99669-44-0;2-(2-Aminoethylamino)-pyridine dihydrochloride;2-(2-aminoethylamino)-pyridinedihydrochloride;N'-pyridin-2-ylethane-1,2-diamine;dihydrochloride;MFCD03427478;N1-(PYRIDIN-2-YL)ETHANE-1,2-DIAMINE DIHYDROCHLORIDE;2-(2-aminoethylamino)-pyridine 2 hcl;SCHEMBL5270311;DTXSID40557806;YJGUUWHSAANPMU-UHFFFAOYSA-N;ZDA66944;2-(2-Aminoethylamino)pyridine diHCl;AKOS015996756;FS-4789;2-(2-Aminoethylamino)-pyridine x 2 HCl;2-(2-pyridylamino)ethylamine dihydrochloride;CS-0270566;EN300-31752;C78639;N1-2-PYRIDINYL-1,2-ETHANEDIAMINE 2HCL;2-[(2-Aminoethyl)amino]pyridine dihydrochloride;2-[(2-amino-1-ethyl)amino]pyridine dihydrochloride;N~1~-(Pyridin-2-yl)ethane-1,2-diamine--hydrogen chloride (1/2)

Chemical Property of 2-(2-Aminoethylamino)-pyridine dihydrochloride

Chemical Property:

• Vapor Pressure: 2.57E-05mmHg at 25°C
• Boiling Point: 353.1oC at 760 mmHg
• Flash Point: 167.3oC
• PSA: 50.94000
• LogP: 2.82950
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 209.0486528
• Heavy Atom Count: 12
• Complexity: 84.9

Purity/Quality:

98%Min ^*data from raw suppliers

N1-2-Pyridinyl-1,2-ethanediamineDihydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=NC(=C1)NCCN.Cl.Cl

Technology Process of 2-(2-Aminoethylamino)-pyridine dihydrochloride

There total 3 articles about 2-(2-Aminoethylamino)-pyridine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

[2-(Pyridin-2-ylamino)-ethyl]-carbamic acid tert-butyl ester (187339-13-5) → N1-pyridin-2-ylethane-1,2-diamine dihydrochloride (99669-44-0,114623-01-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃;

DOI:10.1016/S0960-894X(99)00282-6

Reference yield: 62.0%

2-chloropyridine (109-09-1) + ethylenediamine (107-15-3,85404-18-8) → N1-pyridin-2-ylethane-1,2-diamine dihydrochloride (99669-44-0,114623-01-7)

Guidance literature:

With hydrogenchloride; for 8h; Heating;

DOI:10.1246/bcsj.61.4315

Reference yield:

2-[[2-(Boc-amino)ethyl]amino]pyridine-N-oxide (187339-12-4) → N1-pyridin-2-ylethane-1,2-diamine dihydrochloride (99669-44-0,114623-01-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / cyclohexene / 10 percent Pd/C / propan-2-ol / Heating

2: 95 percent / 4 N HCl / dioxane; CH₂Cl₂ / 0 - 20 °C

With hydrogenchloride; cyclohexene; palladium on activated charcoal; In 1,4-dioxane; dichloromethane; isopropyl alcohol;

DOI:10.1016/S0960-894X(99)00282-6

upstream raw materials:

2-chloropyridine

ethylenediamine

[2-(Pyridin-2-ylamino)-ethyl]-carbamic acid tert-butyl ester

2-[[2-(Boc-amino)ethyl]amino]pyridine-N-oxide

Refernces

• 1、 Keenan, Richard M.,Miller, William H.,Barton, Linda S.,Bondinell, William E.,Cousins, Russell D.,Eppley, Daniel F.,Hwang, Shing-Mei,Kwon, Chet,Lago, M. Amparo,Nguyen, Thomas T.,Smith, Brian R.,Uzinskas, Irene N.,Yuan, Catherine C. K.. "Orally bioavailable nonpeptide vitronectin receptor antagonists containing 2-aminopyridine arginine mimetics". . p. 1801 - 1806. Retrieved 2007/10/03.
• 2、 Mega, Tomohiro,Hamazume, Yasuki,Ikenaka, Tokuji. "Synthesis of Fluorescent Amino Acids and Peptides with 2-Aminopyridine at the Carboxyl or Amino Terminus". . p. 4315 - 4322. Retrieved 2007/10/02.