1-benzyl-4-bromo-indole

Base Information

• Chemical Name: 1-benzyl-4-bromo-indole
• CAS No.: 481630-48-2
• Molecular Formula: C15H12BrN
• Molecular Weight: 286.171
• Hs Code.: 2933990090
• Mol file: 481630-48-2.mol

Synonyms:1-Benzyl-4-brom-indol;1-BENZYL-4-BROMO-1H-INDOLE;I14-9988;1-benzyl-4-bromo-indole;4-bromo-1-benzylindole;

Chemical Property of 1-benzyl-4-bromo-indole

Chemical Property:

• Boiling Point: 425.292 °C at 760 mmHg
• Flash Point: 211.009 °C
• PSA: 4.93000
• Density: 1.351 g/cm³
• LogP: 4.45210
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1-Benzyl-4-bromo-1H-indole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-benzyl-4-bromo-indole

There total 2 articles about 1-benzyl-4-bromo-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

4-bromo-1H-indole (52488-36-5) + benzyl bromide (100-39-0) → 1‐benzyl‐4‐bromo‐1H‐indole (481630-48-2)

Guidance literature:

4-bromo-1H-indole; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 0.666667h;

benzyl bromide; In N,N-dimethyl-formamide; mineral oil; at 0 - 45 ℃; for 1h;

DOI:10.1016/j.ejmech.2020.112916

Reference yield:

4-bromo-1H-indole (52488-36-5) + benzyl chloride (100-44-7) → 1‐benzyl‐4‐bromo‐1H‐indole (481630-48-2)

Guidance literature:

With diethyl ether; ammonia; sodium amide;

Reference yield: 98.0%

1‐benzyl‐4‐bromo‐1H‐indole (481630-48-2) + N-[1-(3-Methoxy-phenyl)-meth-(E)-ylidene]-4-methyl-benzenesulfonamide (160955-96-4) → (R)-N-((1-benzyl-4-bromo-1H-indol-3-yl)(3-methoxyphenyl)methyl)-4-methylbenzenesulfonamide

Guidance literature:

With ethane-1,2-disulphonic acid; C₈₂H₅₆F₁₂N₄O₈S₂; In diethyl ether; at -40 ℃; for 24h; enantioselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.202003673

upstream raw materials:

4-bromo-1H-indole

benzyl chloride

benzyl bromide

Downstream raw materials:

1-benzyl-4-(4-(trifluoromethoxy)phenyl)-1H-indole

1-Benzyl₄-[4-(trifluoromethyl)phenyl]-1H-indole

4-N-acetylamino-1-benzylindole

C₂₄H₂₉N₃O₂