2-tert-butyl 3-ethyl 1,2-dihydroisoquinoline-2,3- dicarboxylate

Base Information

• Chemical Name: 2-tert-butyl 3-ethyl 1,2-dihydroisoquinoline-2,3- dicarboxylate
• CAS No.: 298209-94-6
• Molecular Formula: C17H21NO4
• Molecular Weight: 303.35
• Mol file: 298209-94-6.mol

Synonyms:2-TERT-BUTYL 3-ETHYL 1,2-DIHYDROISOQUINOLINE-2,3-DICARBOXYLATE;

Chemical Property of 2-tert-butyl 3-ethyl 1,2-dihydroisoquinoline-2,3- dicarboxylate

Chemical Property:

• PSA: 55.84000
• LogP: 3.27920

Purity/Quality:

97% ^*data from raw suppliers

2-tert-Butyl3-ethylisoquinoline-2,3(1H)-dicarboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-tert-butyl 3-ethyl 1,2-dihydroisoquinoline-2,3- dicarboxylate

There total 3 articles about 2-tert-butyl 3-ethyl 1,2-dihydroisoquinoline-2,3- dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(2-(bromomethyl)benzyl)triphenyl-1-phosphonium bromide (67219-44-7) + ethyl 2-{[(tert-butoxy)carbonyl]amino}-2-oxoacetate (216959-34-1) → ethyl 2-tert-butoxycarbonyl-1,2-dihydroisoquinoline-3-carboxylate (298209-94-6)

Guidance literature:

With potassium carbonate; In 1,2-dimethoxyethane; at 85 ℃; for 8h;

DOI:10.1021/jo9917994

Reference yield:

ethoxycarbonylcarbonyl isocyanate (66913-88-0) → ethyl 2-tert-butoxycarbonyl-1,2-dihydroisoquinoline-3-carboxylate (298209-94-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / diethyl ether / 0 - 20 °C

2: 80 percent / K₂CO₃ / 1,2-dimethoxy-ethane / 8 h / 85 °C

With potassium carbonate; In 1,2-dimethoxyethane; diethyl ether; 1: Addition / 2: cyclocondensation;

DOI:10.1021/jo9917994

Reference yield:

α,α'-dibromo-o-xylene (91-13-4) → ethyl 2-tert-butoxycarbonyl-1,2-dihydroisoquinoline-3-carboxylate (298209-94-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / benzene / 8 h / Heating

2: 80 percent / K₂CO₃ / 1,2-dimethoxy-ethane / 8 h / 85 °C

With potassium carbonate; In 1,2-dimethoxyethane; benzene; 1: Alkylation / 2: cyclocondensation;

DOI:10.1021/jo9917994

upstream raw materials:

(2-(bromomethyl)benzyl)triphenyl-1-phosphonium bromide

ethyl 2-{[(tert-butoxy)carbonyl]amino}-2-oxoacetate

ethoxycarbonylcarbonyl isocyanate

α,α'-dibromo-o-xylene