TERT-BUTYL 4-CYANO-4-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXYLATE

Base Information

• Chemical Name: TERT-BUTYL 4-CYANO-4-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXYLATE
• CAS No.: 614730-96-0
• Molecular Formula: C12H20N2O3
• Molecular Weight: 240.302
• Hs Code.: 2933399090
• Mol file: 614730-96-0.mol

Synonyms:TERT-BUTYL 4-CYANO-4-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXYLATE

Chemical Property of TERT-BUTYL 4-CYANO-4-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXYLATE

Chemical Property:

• Boiling Point: 382.3±27.0 °C(Predicted)
• PKA: 14.94±0.10(Predicted)
• PSA: 73.56000
• Density: 1.14
• LogP: 1.45748
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%Min ^*data from raw suppliers

Tert-butyl4-cyano-4-(hydroxymethyl)-piperidine-1-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 4-CYANO-4-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXYLATE

There total 7 articles about TERT-BUTYL 4-CYANO-4-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-(tert-butyl) 4-ethyl 4-cyanopiperidine-1,4-dicarboxylate (1016258-66-4) → tert-butyl 4-cyano-4-(hydroxymethyl) piperidine-1-carboxylate (614730-96-0)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 - 28 ℃; for 1.5h; Inert atmosphere;

DOI:10.1016/j.bmcl.2012.10.140

Reference yield: 75.0%

tert-butyl 4-cyano-4-((2-(trimethylsilyl)ethoxy)methyl)piperidine-1-carboxylate → tert-butyl 4-cyano-4-(hydroxymethyl) piperidine-1-carboxylate (614730-96-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 80 ℃; for 51h;

Reference yield: 72.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 1-tert-butoxycarbonyl-4-cyanopiperidine (91419-52-2) → tert-butyl 4-cyano-4-(hydroxymethyl) piperidine-1-carboxylate (614730-96-0)

Guidance literature:

1-tert-butoxycarbonyl-4-cyanopiperidine; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 2.5h; Inert atmosphere;

formaldehyd; In tetrahydrofuran; at -78 - 20 ℃; for 15h; Inert atmosphere;

upstream raw materials:

C₁₄H₁₈N₂O

di-tert-butyl dicarbonate

formaldehyd

1-tert-butoxycarbonyl-4-cyanopiperidine

Downstream raw materials:

tert-butyl 4-cyano-4-({[(4-methylphenyl)sulfonyl]oxy}methyl)piperidine-1-carboxylate

N-[[1-[2-(tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)-4-piperidyl]methyl]-3,5-dichlorobenzamide

tert-butyl 4-(aminomethyl)-4-(hydroxymethyl)piperidine-1-carboxylate

tert-butyl 4-((3,5-dichlorobenzamido)methyl)-4-(hydroxymethyl)piperidine-1-carboxylate

Refernces

• 1、 Ishiyama, Takashi,Kanai, Motomu,Maruyama, Katsuya,Oisaki, Kounosuke,Sakai, Kentaro,Seki, Yohei,Togo, Takaya. "Protein Modification at Tyrosine with Iminoxyl Radicals". . p. 19844 - 19855. Retrieved 2021/11/30.
• 2、 -. "QUINAZOLINE COMPOUND FOR EGFR INHIBITION". . . Retrieved 2019/11/21.