N-((4-(4-Fluorobenzyl)morpholin-2-yl)methyl)acetamide

Base Information

• Chemical Name: N-((4-(4-Fluorobenzyl)morpholin-2-yl)methyl)acetamide
• CAS No.: 112913-94-7
• Molecular Formula: C14H19FN2O2
• Molecular Weight: 266.31
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID40443497
• Nikkaji Number: J3.129.278F
• Mol file: 112913-94-7.mol

Synonyms:112913-94-7;N-((4-(4-Fluorobenzyl)morpholin-2-yl)methyl)acetamide;2-Acetylamidomethyl-4-(4-fluorobenzyl)morpholine;N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]acetamide;2-acetylaminomethyl-4-(4-fluorobenzyl)morpholine;N-[[4-(4-Fluorobenzyl)-2-morpholinyl]methyl]acetamide;MFCD16619692;N-({4-[(4-FLUOROPHENYL)METHYL]MORPHOLIN-2-YL}METHYL)ACETAMIDE;2-Acetylaminomethyl-4-(4-fluorobenzyl)-morpholine;SCHEMBL7370883;AMY8684;DTXSID40443497;IYDYAXXGLUZOJN-UHFFFAOYSA-N;AC2963;AKOS015918415;DS-17859;SY033824;CS-0153951;Fluorobenzyl)morpholin-2-yl)methyl)acetamide;FT-0656848;A802699;J-507703

Chemical Property of N-((4-(4-Fluorobenzyl)morpholin-2-yl)methyl)acetamide

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 120-122 °C
• Refractive Index: 1.521
• Boiling Point: 429.984 °C at 760 mmHg
• PKA: 15.80±0.46(Predicted)
• Flash Point: 213.847 °C
• Density: 1.152 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 266.14305602
• Heavy Atom Count: 19
• Complexity: 293

Purity/Quality:

99% , ^*data from raw suppliers

N-[[4-(4-Fluorobenzyl)-2-morpholinyl]methyl]acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NCC1CN(CCO1)CC2=CC=C(C=C2)F

Technology Process of N-((4-(4-Fluorobenzyl)morpholin-2-yl)methyl)acetamide

There total 5 articles about N-((4-(4-Fluorobenzyl)morpholin-2-yl)methyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(N-acetylaminomethyl)morpholine (112913-95-8) + 1-chloromethyl-4-fluorobenzene (352-11-4) → 2-<(acetylamino)methyl>-4-(4-fluorobenzyl)morpholine (112913-94-7)

Guidance literature:

With potassium iodide; potassium carbonate; In butanone;

Reference yield:

2-(N-acetylaminomethyl)-4-benzylmorpholine (112913-96-9) → 2-<(acetylamino)methyl>-4-(4-fluorobenzyl)morpholine (112913-94-7)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂, AcOH / 10percent Pd/C / ethanol / 60 °C

2: K₂CO₃, KI / butan-2-one / 17 h / Heating

With hydrogen; potassium carbonate; acetic acid; potassium iodide; palladium on activated charcoal; In ethanol; butanone;

DOI:10.1021/jm00106a023

Reference yield:

<2-(acetylamino)methyl>morpholine acetyl salt (131322-23-1) → 2-<(acetylamino)methyl>-4-(4-fluorobenzyl)morpholine (112913-94-7)

Guidance literature:

With potassium carbonate; potassium iodide; In butanone; for 17h; Heating;

DOI:10.1021/jm00106a023

upstream raw materials:

acetic anhydride

2-aminomethyl-4-(4-fluoro-benzyl) morpholine

<2-(acetylamino)methyl>morpholine acetyl salt

2-(4-fluoro-benzyl-amino)-ethanol

Downstream raw materials:

2-aminomethyl-4-(4-fluoro-benzyl) morpholine

4-Amino-5-chloro-N-[4-(4-fluoro-benzyl)-morpholin-2-ylmethyl]-2-methoxy-benzamide

4-acetylamino-5-chloro-2-ethoxy-N-[[4-(4-fluorobenzyl)-2-morpholinyl]methyl]benzamide

mosapride