URB447

Base Information

Chemical Name:URB447
CAS No.:1132922-57-6
Molecular Formula:C25H21ClN2O
Molecular Weight:400.908
Hs Code.:
Mol file:1132922-57-6.mol

Synonyms:URB447;

Suppliers and Price of URB447

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
URB447
5mg
$ 520.00

TRC
URB447
1mg
$ 125.00

Cayman Chemical
URB447 ≥98%
50mg
$ 528.00

Cayman Chemical
URB447 ≥98%
25mg
$ 297.00

Cayman Chemical
URB447 ≥98%
10mg
$ 125.00

Cayman Chemical
URB447 ≥98%
5mg
$ 66.00

AK Scientific
{4-Amino-1-[(4-chlorophenyl)methyl]-2-methyl-5-phenyl-1H-pyrrol-3-yl}(phenyl)methanone
25mg
$ 500.00

Total 12 raw suppliers

Chemical Property of URB447

Chemical Property:

Melting Point:128-130 °C(Solv: ethyl acetate (141-78-6); ligroine (8032-32-4))
Boiling Point:568.6±50.0 °C(Predicted)
PKA:1.11±0.18(Predicted)
PSA：48.02000
Density:1.20±0.1 g/cm3(Predicted)
LogP:6.55960

Purity/Quality:

99% ^*data from raw suppliers

URB447 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses URB447 is a CB1 antagonist and CB2 agonist with anti-obesity and appetite suppressant properties. URB447 does not cross the blood brain barrier.

Technology Process of URB447

There total 8 articles about URB447 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1132922-53-2
{1-(4-chlorobenzyl)-4-[(4-chlorobenzylidene)amino]-2-methyl-5-phenyl-1H-pyrrol-3-yl}(phenyl)methanone

: 1132922-57-6
URB₄₄₇

Guidance literature:: With hydrogenchloride; water; In N,N-dimethyl-formamide; at 20 ℃; for 6h;
DOI:10.1016/j.bmcl.2008.12.059

Reference yield: 66.0%

: tert-butyl 4-benzoyl-1-(4-chlorobenzyl)-5-methyl-2-phenyl-1H-pyrrol-3-yl(tosyl)carbamate

: 1132922-57-6
URB₄₄₇

Guidance literature:: With perchloric acid; acetic acid; at 90 ℃; for 1.5h;
DOI:10.1002/chem.201406460

Reference yield:

: 93-91-4
1-phenylbutan-1,3-dione

: 1132922-57-6
URB₄₄₇

Guidance literature:: Multi-step reaction with 7 steps

1.1: phosgene / chloroform / 0.33 h / 0 °C / Reflux

2.1: sodium azide / methanol; water / 4 h / 0 °C

3.1: toluene / 2 h / 85 °C

4.1: bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]} / dichloromethane / 90 °C / Inert atmosphere; Schlenk technique

5.1: dmap; triethylamine / tetrahydrofuran / 110 °C

6.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

6.2: 3 h / 20 °C / Inert atmosphere

7.1: perchloric acid; acetic acid / 1.5 h / 90 °C

With phosgene; dmap; sodium azide; perchloric acid; bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]}; sodium hydride; acetic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene;
DOI:10.1002/chem.201406460