(4-BROMO-PHENYL)-TERT-BUTOXYCARBONYLAMINO-ACETIC ACID

Base Information

• Chemical Name: (4-BROMO-PHENYL)-TERT-BUTOXYCARBONYLAMINO-ACETIC ACID
• CAS No.: 917925-71-4
• Molecular Formula: C13H16BrNO4
• Molecular Weight: 330.178
• Hs Code.: 2924299090
• Mol file: 917925-71-4.mol

Synonyms:(4-BROMO-PHENYL)-TERT-BUTOXYCARBONYLAMINO-ACETIC ACID;2-(Boc-aMino)-2-(4-broMophenyl)acetic Acid;2-(4-Bromophenyl)-2-{[(tert-butoxy)-carbonyl]amino}acetic acid

Chemical Property of (4-BROMO-PHENYL)-TERT-BUTOXYCARBONYLAMINO-ACETIC ACID

Chemical Property:

• Boiling Point: 465.1±40.0 °C(Predicted)
• PKA: 3.38±0.10(Predicted)
• PSA: 75.63000
• Density: 1.443±0.06 g/cm3(Predicted)
• LogP: 3.49040
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-(4-Bromophenyl)-2-{[(tert-butoxy)-carbonyl]amino}acetic acid >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(Boc-amino)-2-(4-bromophenyl)acetic acid is used as a reactant in the preparation of hydroxamic acid analogs as dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases.

Technology Process of (4-BROMO-PHENYL)-TERT-BUTOXYCARBONYLAMINO-ACETIC ACID

There total 1 articles about (4-BROMO-PHENYL)-TERT-BUTOXYCARBONYLAMINO-ACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + 2-amino-2-(4-bromophenyl)acetic acid (119397-06-7,71079-03-3) → 2-(4-bromophenyl)-2-((tert-butoxycarbonyl)amino)acetic acid (917925-71-4,1228570-47-5)

Guidance literature:

di-tert-butyl dicarbonate; 2-amino-2-(4-bromophenyl)acetic acid; With dmap; triethylamine; In 1,4-dioxane; water; for 3h;

With hydrogenchloride; In 1,4-dioxane; water; ethyl acetate;

Reference yield: 60.0%

2-(4-bromophenyl)-2-((tert-butoxycarbonyl)amino)acetic acid (917925-71-4,1228570-47-5) + methyl iodide (74-88-4) → methyl 2-(4-bromophenyl)-2-((tert-butoxycarbonyl)amino)acetate (709665-73-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 75 ℃; for 12h;

Reference yield: 50.0%

2-(4-bromophenyl)-2-((tert-butoxycarbonyl)amino)acetic acid (917925-71-4,1228570-47-5) + benzyl bromide (100-39-0) → benzyl 2-(4-bromophenyl)-2-((tert-butoxycarbonyl)amino)acetate (947182-42-5)

Guidance literature:

With potassium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

upstream raw materials:

di-tert-butyl dicarbonate

2-amino-2-(4-bromophenyl)acetic acid

Downstream raw materials:

benzyl 2-(4-bromophenyl)-2-((tert-butoxycarbonyl)amino)acetate

[(4-bromo-phenyl)-(5-phenyl-1H-imidazol-2-yl)-methyl]-carbamic acid tert-butyl ester

methyl 2-(4-bromophenyl)-2-((tert-butoxycarbonyl)amino)acetate

2-([1,1'-biphenyl]-4-yl)-2-((tert-butoxycarbonyl)amino)acetic acid