P-[[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]methyl]phosphonic acid diethyl ester

Base Information

Chemical Name:P-[[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]methyl]phosphonic acid diethyl ester
CAS No.:154057-57-5
Molecular Formula:C23H25FNO3P
Molecular Weight:413.429
Hs Code.:
Mol file:154057-57-5.mol

Synonyms:diethyl {[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]methyl}phosphonate;yl]methyl]phosphonic acid diethyl ester;diethyl <<(diethylamino)sulfonyl>methyl>phosphonate;;Phosphonic acid,[[(diethylamino)sulfonyl]methyl]-,dimethyl ester;;

Suppliers and Price of P-[[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]methyl]phosphonic acid diethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 9 raw suppliers

Chemical Property of P-[[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]methyl]phosphonic acid diethyl ester

Chemical Property:

Appearance/Colour:light yellow liquid
PSA：58.23000
Density:1.239
LogP:6.68440

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of P-[[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]methyl]phosphonic acid diethyl ester

There total 3 articles about P-[[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]methyl]phosphonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 78-40-0
triethyl phosphate

: 154057-56-4
3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)-quinoline

: 154057-57-5
diethyl <2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl>methylphosphonate

Guidance literature:: In toluene; for 12h; Heating;
DOI:10.1246/bcsj.68.364

Reference yield: 96.0%

: 154057-56-4
3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)-quinoline

: 122-52-1
triethyl phosphite

: 154057-57-5
diethyl <2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl>methylphosphonate

Guidance literature:: In toluene; at 100 - 110 ℃; Temperature; Solvent;

Reference yield:

: 121660-11-5
2-cyclopropyl-4-(4-fluorophenyl)-3-(hydroxymethyl)quinoline

: 154057-57-5
diethyl <2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl>methylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / phosphorus tribromide / CH₂Cl₂; toluene / 3 h / Ambient temperature

2: 100 percent / toluene / 12 h / Heating

With phosphorus tribromide; In dichloromethane; toluene;
DOI:10.1246/bcsj.68.364