Diethyl 2-(pyrimidin-2-yl)malonate

Base Information

Chemical Name:Diethyl 2-(pyrimidin-2-yl)malonate
CAS No.:164296-40-6
Molecular Formula:C11H14N2O4
Molecular Weight:238.24
Hs Code.:2933599090
DSSTox Substance ID:DTXSID10367878
Wikidata:Q82154032
Mol file:164296-40-6.mol

Synonyms:164296-40-6;Diethyl 2-(pyrimidin-2-yl)malonate;2-(2-Pyrimidinyl)propanedioic acid 1,3-diethyl ester;diethyl 2-pyrimidin-2-ylpropanedioate;Diethyl (pyrimidin-2-yl)propanedioate;1,3-diethyl 2-(pyrimidin-2-yl)propanedioate;Diethyl2-(pyrimidin-2-yl)malonate;SCHEMBL896384;diethyl (2-pyrimidinyl)malonate;DTXSID10367878;Propanedioic acid, 2-(2-pyrimidinyl)-, 1,3-diethyl ester;Cl-6002;Diethyl 2-(2-pyrimidinyl)malonate;MFCD00720665;AKOS003617868;DS-0328;SB60638;CS-0151884;A882469;J-505700;2-(2-Pyrimidinyl)propanedioic acid1,3-diethyl ester

Suppliers and Price of Diethyl 2-(pyrimidin-2-yl)malonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Diethyl2-(Pyrimidin-2-yl)malonate
10mg
$ 45.00

Matrix Scientific
2-(2-Pyrimidinyl)propanedioic acid1,3-diethyl ester 95+%
5g
$ 1298.00

Matrix Scientific
2-(2-Pyrimidinyl)propanedioic acid1,3-diethyl ester 95+%
1g
$ 416.00

Crysdot
Diethyl2-(pyrimidin-2-yl)malonate 95+%
10g
$ 277.00

Crysdot
Diethyl2-(pyrimidin-2-yl)malonate 95+%
25g
$ 614.00

Chemenu
2-(2-Pyrimidinyl)propanedioicacid1,3-diethylester 95%
25g
$ 580.00

Chemenu
2-(2-Pyrimidinyl)propanedioicacid1,3-diethylester 95%
5g
$ 184.00

Chemenu
2-(2-Pyrimidinyl)propanedioicacid1,3-diethylester 95%
10g
$ 262.00

Biosynth Carbosynth
Diethyl 2-(pyrimidin-2-yl)malonate
5 g
$ 385.00

Biosynth Carbosynth
Diethyl 2-(pyrimidin-2-yl)malonate
2 g
$ 193.00

Total 22 raw suppliers

Chemical Property of Diethyl 2-(pyrimidin-2-yl)malonate

Chemical Property:

Vapor Pressure:0.000456mmHg at 25°C
Boiling Point:314.8°C at 760 mmHg
Flash Point:144.2°C
PSA：78.38000
Density:1.197g/cm³
LogP:0.68640
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:0.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:238.09535693
Heavy Atom Count:17
Complexity:246

Purity/Quality:

97% ^*data from raw suppliers

Diethyl2-(Pyrimidin-2-yl)malonate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(C1=NC=CC=N1)C(=O)OCC

Technology Process of Diethyl 2-(pyrimidin-2-yl)malonate

There total 4 articles about Diethyl 2-(pyrimidin-2-yl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 31462-54-1
2-iodopyrimidine

: 105-53-3
diethyl malonate

: 164296-40-6
diethyl 2-(Pyrimidin-2-yl)malonate

Guidance literature:: With 2-Picolinic acid; copper(l) iodide; caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 21h; Inert atmosphere; Schlenk technique;
DOI:10.1021/acs.joc.9b01133

Reference yield: 49.0%

: 4595-60-2
2-bromopyrimidine

: 105-53-3
diethyl malonate

: 164296-40-6
diethyl 2-(Pyrimidin-2-yl)malonate

Guidance literature:: In water; N,N-dimethyl-formamide;

Reference yield:

: 1722-12-9,1195939-87-7
2-chloropyrimidine

: 105-53-3
diethyl malonate

: 164296-40-6
diethyl 2-(Pyrimidin-2-yl)malonate

Guidance literature:: diethyl malonate; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

2-chloropyrimidine; In N,N-dimethyl-formamide; at 100 ℃; for 3h;