N-(4-CHLORO-3-PYRIDINYL)ACETAMIDE

Base Information

• Chemical Name: N-(4-CHLORO-3-PYRIDINYL)ACETAMIDE
• CAS No.: 138769-30-9
• Molecular Formula: C7H7ClN2O
• Molecular Weight: 170.598
• Hs Code.: 2933399090
• Mol file: 138769-30-9.mol

Synonyms:N-(4-CHLORO-3-PYRIDINYL)ACETAMIDE

Chemical Property of N-(4-CHLORO-3-PYRIDINYL)ACETAMIDE

Chemical Property:

• Vapor Pressure: 0.000128mmHg at 25°C
• Boiling Point: 334.4°C at 760 mmHg
• Flash Point: 156°C
• PSA: 41.99000
• Density: 1.336g/cm³
• LogP: 1.76640
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

N-(4-Chloropyridin-3-yl)acetamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-CHLORO-3-PYRIDINYL)ACETAMIDE

There total 3 articles about N-(4-CHLORO-3-PYRIDINYL)ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-(pyridin-3-yl)acetamide (5867-45-8) → N-(4-chloropyridin-3-yl) acetamide (138769-30-9)

Guidance literature:

With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; N-chlorophthalimide; N-tert-butoxycarbonyl-L-phenylalanine; silver(I) triflimide; In 1,2-dichloro-ethane; at 80 ℃; for 6h; Inert atmosphere; Sealed tube;

DOI:10.1002/chem.201700280

Reference yield: 86.0%

3-amino-4-chloropyridine (20511-15-3) + acetyl chloride (75-36-5) → N-(4-chloropyridin-3-yl) acetamide (138769-30-9)

Guidance literature:

In ethyl acetate; at 85 ℃; for 1h;

DOI:10.1002/anie.200702542

Reference yield:

3-amino-4-chloropyridine (20511-15-3) + acetic anhydride (108-24-7) → N-(4-chloropyridin-3-yl) acetamide (138769-30-9)

Guidance literature:

With benzene;

upstream raw materials:

3-amino-4-chloropyridine

acetic anhydride

acetyl chloride

N-(pyridin-3-yl)acetamide

Downstream raw materials:

2-methyl-1-(2-methylphenyl)-1H-imidazol[4,5-c]pyridine

Refernces

• 1、 Zheng, Nan,Anderson, Kevin W.,Huang, Xiaohua,Nguyen, Hanh Nho,Buchwald, Stephen L.. "A palladium-catalyzed regiospecific synthesis of N-aryl benzimidazoles". . p. 7509 - 7512. Retrieved 2008/09/17.