4-Bromo-2-fluoropyridine-3-carboxaldehyde

Base Information

• Chemical Name: 4-Bromo-2-fluoropyridine-3-carboxaldehyde
• CAS No.: 128071-77-2
• Molecular Formula: C6H3BrFNO
• Molecular Weight: 204
• Hs Code.: 2933399090
• Mol file: 128071-77-2.mol

Synonyms:4-Bromo-2-fluoropyridine-3-carboxaldehyde;4-broMo-2-fluoropyridin-3-carbaldehyde;4-BroMo-2-fluoronicotinaldehyde

Chemical Property of 4-Bromo-2-fluoropyridine-3-carboxaldehyde

Chemical Property:

• Vapor Pressure: 0.00652mmHg at 25°C
• Boiling Point: 271.3°C at 760 mmHg
• PKA: -0.34±0.10(Predicted)
• Flash Point: 117.8°C
• PSA: 29.96000
• Density: 1.778g/cm³
• LogP: 1.79570
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-2-fluoro-3-formylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Bromo-2-fluoropyridine-3-carboxaldehyde

There total 1 articles about 4-Bromo-2-fluoropyridine-3-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-fluoropyridine (372-48-5) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 4-bromo-2-fluoro-pyridine-3-carbaldehyde (128071-77-2)

Guidance literature:

Yield given. Multistep reaction;

DOI:10.1016/0022-328X(90)80210-Q

Reference yield: 82.0%

4-bromo-2-fluoro-pyridine-3-carbaldehyde (128071-77-2) + methylhydrazine (60-34-4) → 4-bromo-1-methylpyrazolo[3,4-b]pyridine (1289150-14-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 50 ℃; for 1h;

Reference yield: 33.3%

4-bromo-2-fluoro-pyridine-3-carbaldehyde (128071-77-2) + 2-fluorophenylhydrazine (2368-80-1) → 4-bromo-1-(2-fluorophenyl)-1H-pyrazolo[3,4-b]pyridine

Guidance literature:

With Isobutyronitrile; caesium carbonate; at 20 - 120 ℃;

upstream raw materials:

2-fluoropyridine

N,N-dimethyl-formamide

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