2,5-Dichloro-4-methylpyrimidine

Base Information

• Chemical Name: 2,5-Dichloro-4-methylpyrimidine
• CAS No.: 1192064-63-3
• Molecular Formula: C5H4Cl2N2
• Molecular Weight: 163.006
• Hs Code.: 2933599090
• Mol file: 1192064-63-3.mol

Synonyms:2,5-Dichloro-4-methyl-pyrimidine

Chemical Property of 2,5-Dichloro-4-methylpyrimidine

Chemical Property:

• Boiling Point: 256.9±20.0 °C(Predicted)
• PKA: -2.35±0.29(Predicted)
• PSA: 25.78000
• Density: 1.404±0.06 g/cm3(Predicted)
• LogP: 2.09180
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

2,5-Dichloro-4-methylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,5-Dichloro-4-methylpyrimidine

There total 4 articles about 2,5-Dichloro-4-methylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

methylmagnesium bromide (75-16-1) + 2,4,5-trichloropyrimidine (5750-76-5) → 2,5-dichloro-4-methylpyrimidine (1192064-63-3)

Guidance literature:

With iron(III)-acetylacetonate; In tetrahydrofuran; NMP (N-methylpyrrolidone); diethyl ether; at 0 ℃; for 0.5h;

Reference yield: 60.0%

tetramethylstannane (594-27-4) + 2,4,5-trichloropyrimidine (5750-76-5) → 2,5-dichloro-4-methylpyrimidine (1192064-63-3)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium chloride; In N,N-dimethyl-formamide; at 110 ℃; for 4h; regioselective reaction;

DOI:10.1016/j.bmcl.2014.12.081

Reference yield:

methylmagnesium bromide (75-16-1) + 2,4,5-trichloropyrimidine (5750-76-5) → 2,5-dichloro-4-methylpyrimidine (1192064-63-3) + 5-Chloro-2,4-dimethylpyrimidine (75712-73-1)

Guidance literature:

iron(III)-acetylacetonate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 20 ℃; Inert atmosphere;

upstream raw materials:

methylmagnesium bromide

2,4,5-trichloropyrimidine

tetramethylstannane

Downstream raw materials:

4-(5-{3-[(5-chloro-4-methylpyrimidin-2-yl)amino]-5-methylphenyl}-1,3-thiazol-2-yl)-1,4-diazepan-2-one

Refernces

• 1、 -. "DISUBSTITUTED OCTAHY-DROPYRROLO [3,4-C] PYRROLES AS OREXIN RECEPTOR MODULATORS". Page/Page column 81. . Retrieved 2012/11/07.
• 2、 -. "DISUBSTITUTED OCTAHY - DROPYRROLO [3,4-C] PYRROLES AS OREXIN RECEPTOR MODULATORS". Page/Page column 81. . Retrieved 2011/05/06.