4-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE

Base Information

• Chemical Name: 4-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE
• CAS No.: 1000340-34-0
• Molecular Formula: C₇H₄BrIN₂
• Molecular Weight: 322.931
• Hs Code.: 2933399990
• Mol file: 1000340-34-0.mol

Synonyms:4-bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 4-bromo-3-iodo-

Chemical Property of 4-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE

Chemical Property:

• PSA: 28.68000
• LogP: 2.93000
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99%, ^*data from raw suppliers

4-Bromo-3-iodo-7-azaindole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE

There total 1 articles about 4-BROMO-3-IODO-1H-PYRROLO[2,3-B]PYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-bromo-7-azaindole (348640-06-2) → 4-bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine (1000340-34-0)

Guidance literature:

With N-iodo-succinimide; In dichloromethane; at 0 ℃; for 1h; Product distribution / selectivity; Inert atmosphere;

Reference yield:

4-bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine (1000340-34-0) → N-(1-isopropyl-3-(3-(pyrrolidin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide (1415925-21-1)

Guidance literature:

Multi-step reaction with 3 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / 1 h / 0 °C

2: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 2 h / 65 °C

3: DavePhos; caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation

With di-isopropyl azodicarboxylate; sodium carbonate; caesium carbonate; triphenylphosphine; DavePhos; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; water; acetonitrile;

Reference yield:

4-bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine (1000340-34-0) → 4-bromo-1-isopropyl-3-(3-(pyrrolidin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:

Multi-step reaction with 2 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / 1 h / 0 °C

2: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 2 h / 65 °C

With di-isopropyl azodicarboxylate; sodium carbonate; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; In water; acetonitrile;

upstream raw materials:

4-bromo-7-azaindole

Downstream raw materials:

GSK2795039

N-(1-isopropyl-3-(3-(pyrrolidin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide

N-(3-(5-fluoro-1-methylindolin-6-yl)-1-(1-methylazetidin-3-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl)benzenesulfonamide

tert-butyl 3-(3-(5-fluoro-1-methylindolin-6-yl)-4-(phenylsulfonamido)-1H-pyrrolo[2,3-b]pyridin-1-yl)azetidine-1-carboxylate

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