N-(1-isopropyl-3-(3-(pyrrolidin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide

Base Information

Chemical Name:N-(1-isopropyl-3-(3-(pyrrolidin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide
CAS No.:1415925-21-1
Molecular Formula:C₂₄H₂₈N₆O₂S
Molecular Weight:464.591
Hs Code.:

Synonyms:N-(1-isopropyl-3-(3-(pyrrolidin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide

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Chemical Property of N-(1-isopropyl-3-(3-(pyrrolidin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide

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Technology Process of N-(1-isopropyl-3-(3-(pyrrolidin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide

There total 4 articles about N-(1-isopropyl-3-(3-(pyrrolidin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88398-97-4
1-methyl-1H-pyrazole-3-sulfonamide

: 4-bromo-1-isopropyl-3-(3-(pyrrolidin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridine

: 1415925-21-1
N-(1-isopropyl-3-(3-(pyrrolidin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide

Guidance literature:: With caesium carbonate; DavePhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; at 150 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 348640-06-2
4-bromo-7-azaindole

: 1415925-21-1
N-(1-isopropyl-3-(3-(pyrrolidin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-iodo-succinimide / dichloromethane / 1 h / 0 °C / Inert atmosphere

2: triphenylphosphine; di-isopropyl azodicarboxylate / 1 h / 0 °C

3: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 2 h / 65 °C

4: DavePhos; caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation

With N-iodo-succinimide; di-isopropyl azodicarboxylate; sodium carbonate; caesium carbonate; triphenylphosphine; DavePhos; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; acetonitrile;

Reference yield:

: 1000340-34-0
4-bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine

: 1415925-21-1
N-(1-isopropyl-3-(3-(pyrrolidin-1-yl)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1-methyl-1H-pyrazole-3-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / 1 h / 0 °C

2: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / acetonitrile; water / 2 h / 65 °C

3: DavePhos; caesium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 150 °C / Inert atmosphere; Microwave irradiation

With di-isopropyl azodicarboxylate; sodium carbonate; caesium carbonate; triphenylphosphine; DavePhos; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; water; acetonitrile;