5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE

Base Information

• Chemical Name: 5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE
• CAS No.: 114744-50-2
• Molecular Formula: C9H10BrN
• Molecular Weight: 212.089
• Hs Code.: 2933499090
• Mol file: 114744-50-2.mol

Synonyms:5-bromo-tetrahydroquinoline

Chemical Property of 5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE

Chemical Property:

• Boiling Point: 299.676 °C at 760 mmHg
• PKA: 4.19±0.20(Predicted)
• Flash Point: 135.039 °C
• PSA: 12.03000
• Density: 1.428 g/cm³
• LogP: 3.74720
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Bromo-1,2,3,4-tetrahydroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE

There total 8 articles about 5-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

5-bromoquinoline (4964-71-0) → 5-bromo-1,2,3,4-tetrahydroquinoline (114744-50-2)

Guidance literature:

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; hydrogen; tricyclohexylphosphine; In ethanol; at 20 ℃; for 10h; under 760.051 Torr;

Reference yield: 85.4%

→ 5-bromo-1,2,3,4-tetrahydroquinoline (114744-50-2)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; phenylsilane; In methanol; at 45 ℃; for 24h; Inert atmosphere; Sealed tube;

Reference yield: 77.0%

tert-butyl (3-(2-bromophenyl)propyl)(tosyloxy)carbamate → 5-bromo-1,2,3,4-tetrahydroquinoline (114744-50-2)

Guidance literature:

With bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]}; trifluoroacetic acid; In 2,2,2-trifluoroethanol; at 0 - 20 ℃; for 22h; regioselective reaction;

DOI:10.1126/science.aaf8713

upstream raw materials:

4-bromo-1-indanone oxime

5-bromoquinoline

4-bromo-2,3-dihydroinden-1-one

methanol

Refernces

• 1、 Chen, Xiuwen,Zhao, He,Chen, Chunlian,Jiang, Huanfeng,Zhang, Min. "Iridium-catalyzed dehydrogenative α-Functionalization of (Hetero)aryl-Fused cyclic secondary amines with indoles". . p. 1171 - 1174. Retrieved 2018.
• 2、 Falk, Eric,Gasser, Valentina C. M.,Morandi, Bill. "Synthesis of N-Alkyl Anilines from Arenes via Iron-Promoted Aromatic C-H Amination". supporting information. p. 1422 - 1426. Retrieved 2021/03/08.
• 3、 Gao, Chao,Xuan, Qingqing,Song, Qiuling. "Cu-Catalyzed Chemoselective Reduction of N-Heteroaromatics with NH3·BH3 in Aqueous Solution". supporting information. p. 2504 - 2508. Retrieved 2021/07/31.