Technology Process of 1-(5-(8-((4-(morpholine-4-carbonyl)phenyl)amino)imidazo[1,2-a]pyrazin-6-yl)-3,4-dihydroquinolin-1(2H)-yl)ethanone
There total 6 articles about 1-(5-(8-((4-(morpholine-4-carbonyl)phenyl)amino)imidazo[1,2-a]pyrazin-6-yl)-3,4-dihydroquinolin-1(2H)-yl)ethanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate;
In
1,4-dioxane;
at 100 ℃;
for 2h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere
2: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C
3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 110 °C
4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; palladium 10% on activated carbon; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
1,4-dioxane; methanol; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: triethylamine / dichloromethane / 2 h / 20 °C
2: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / 1,4-dioxane / 2 h / 100 °C
3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; potassium carbonate; triethylamine;
In
1,4-dioxane; dichloromethane;