1-(5-(8-((4-(morpholine-4-carbonyl)phenyl)amino)imidazo[1,2-a]pyrazin-6-yl)-3,4-dihydroquinolin-1(2H)-yl)ethanone

Base Information

Chemical Name:1-(5-(8-((4-(morpholine-4-carbonyl)phenyl)amino)imidazo[1,2-a]pyrazin-6-yl)-3,4-dihydroquinolin-1(2H)-yl)ethanone
CAS No.:1622173-42-5
Molecular Formula:C₂₈H₂₈N₆O₃
Molecular Weight:496.569
Hs Code.:

Synonyms:1-(5-(8-((4-(morpholine-4-carbonyl)phenyl)amino)imidazo[1,2-a]pyrazin-6-yl)-3,4-dihydroquinolin-1(2H)-yl)ethanone

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Chemical Property of 1-(5-(8-((4-(morpholine-4-carbonyl)phenyl)amino)imidazo[1,2-a]pyrazin-6-yl)-3,4-dihydroquinolin-1(2H)-yl)ethanone

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Technology Process of 1-(5-(8-((4-(morpholine-4-carbonyl)phenyl)amino)imidazo[1,2-a]pyrazin-6-yl)-3,4-dihydroquinolin-1(2H)-yl)ethanone

There total 6 articles about 1-(5-(8-((4-(morpholine-4-carbonyl)phenyl)amino)imidazo[1,2-a]pyrazin-6-yl)-3,4-dihydroquinolin-1(2H)-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 886854-84-8
[4-(6-bromo-imidazo[1,2-a]pyrazin-8-ylamino)-phenyl]-morpholin-4-yl-methanone

: 1622173-51-6
1-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroquinolin-1(2H)-yl)ethanone

: 1622173-42-5
1-(5-(8-((4-(morpholine-4-carbonyl)phenyl)amino)imidazo[1,2-a]pyrazin-6-yl)-3,4-dihydroquinolin-1(2H)-yl)ethanone

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,4-dioxane; at 100 ℃; for 2h; Inert atmosphere;

Reference yield:

: 62-23-7
4-nitro-benzoic acid

: 1622173-42-5
1-(5-(8-((4-(morpholine-4-carbonyl)phenyl)amino)imidazo[1,2-a]pyrazin-6-yl)-3,4-dihydroquinolin-1(2H)-yl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 h / 110 °C

4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

: 114744-50-2
5-bromo-1,2,3,4-tetrahydroquinoline

: 1622173-42-5
1-(5-(8-((4-(morpholine-4-carbonyl)phenyl)amino)imidazo[1,2-a]pyrazin-6-yl)-3,4-dihydroquinolin-1(2H)-yl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 2 h / 20 °C

2: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 2 h / 100 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane / 2 h / 100 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; potassium carbonate; triethylamine; In 1,4-dioxane; dichloromethane;