N-Acetyl-dl-norleucine

Base Information

• Chemical Name: N-Acetyl-dl-norleucine
• CAS No.: 7682-16-8
• Molecular Formula: C8H15NO3
• Molecular Weight: 173.212
• Hs Code.: 2924199090
• NSC Number: 203817,203815,203811
• UNII: GGG86KQG5L
• DSSTox Substance ID: DTXSID401032822
• Nikkaji Number: J364.296H
• Mol file: 7682-16-8.mol

Synonyms:N-Acetyl-dl-norleucine;7682-16-8;2-acetamidohexanoic acid;Ac-DL-Nle-OH;ACETYL-DL-2-AMINOHEXANOIC ACID;DL-norleucine, N-acetyl-;GGG86KQG5L;(+/-)-N-Acetylnorleucine;NSC-203815;Acetyl-DL-Norleucine;2-(acetylamino)hexanoic acid;NSC203815;N-Acetylnorleucine #;Acetyl-D,L-norleucin;2-acetamidohexanoicacid;Maybridge1_002303;UNII-GGG86KQG5L;DivK1c_001055;SCHEMBL137690;HMS548A15;CHEBI:170072;JDMCEGLQFSOMQH-UHFFFAOYSA-N;DTXSID401032822;MFCD00037272;NSC203811;NSC203817;AKOS008986601;HY-W142016;NSC 203815;NSC-203811;CDS1_000015;AS-59472;A0750;CS-0201802;FT-0636563;FT-0695160;D88313;EN300-868887;A838846

Chemical Property of N-Acetyl-dl-norleucine

Chemical Property:

• Vapor Pressure: 9.05E-07mmHg at 25°C
• Melting Point: 108 ºC
• Refractive Index: 1.46
• Boiling Point: 378.3 ºC at 760 mmHg
• Flash Point: 182.6 ºC
• PSA: 66.40000
• Density: 1.072 g/cm³
• LogP: 1.15680
• Solubility.: soluble in Methanol
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 173.10519334
• Heavy Atom Count: 12
• Complexity: 168

Purity/Quality:

98% ^*data from raw suppliers

N-Acetyl-DL-norleucine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCC(C(=O)O)NC(=O)C
• Uses: Substrate for aminoacylase

Technology Process of N-Acetyl-dl-norleucine

There total 6 articles about N-Acetyl-dl-norleucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-acetylnorleucine methyl ester (56247-43-9) → N-acetylnorleucine (7682-16-8)

Guidance literature:

With potassium hydroxide; In ethanol; for 1h; Heating;

DOI:10.1016/S0040-4020(01)86046-4

Reference yield: 81.0%

acetylamino-butyl-malonic acid diethyl ester (62183-10-2) → N-acetylnorleucine (7682-16-8)

Guidance literature:

With sodium hydroxide; Heating;

Reference yield: 71.0%

2-amino-hexanoic acid (616-06-8) + acetic anhydride (108-24-7) → N-acetylnorleucine (7682-16-8)

Guidance literature:

at 15 - 30 ℃; for 4h;

DOI:10.1016/S0957-4166(97)00400-X

upstream raw materials:

2-acetylamino-2-cyano-valeric acid ethyl ester

acetylamino-butyl-malonic acid diethyl ester

2-amino-hexanoic acid

acetic anhydride

Downstream raw materials:

L-Norleucine

N-acetyl-D-norleucine

N-[1-(4-methyl-benzoyl)-pentyl]-acetamide

Refernces

• 1、 Bommarius, Andreas S.,Drauz, Karlheinz,Guenther, Kurt,Knaup, Guenter,Schwarm, Michael. "L-Methionine related 1-amino acids by acylase cleavage of their corresponding N-acetyl-DL-derivatives". . p. 3197 - 3200. Retrieved 2007/10/03.
• 2、 Bretschneider, Thomas,Miltz, Wolfgang,Muenster, Peter,Steglich, Wolfgang. "NEW SYNTHESES OF α-AMINO ACIDS BASED ON N-ACYLIMINO ACETATES". . p. 5403 - 5414. Retrieved 2007/10/02.